Age-Related Gray Matter Shrinkage in a Treatment Naive Actively Drinking Alcohol-Dependent Sample
Age-Related Gray Matter Shrinkage in a Treatment Naive Actively Drinking Alcohol-Dependent Sample
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DOI：
10.1111/j.1530-0277.2009.01079.x
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发表时间：
2010-01-01
影响因子：
3.2
通讯作者：
Barakos, Jerome
中科院分区：
文献类型：
--
作者：
Fein, George;Shimotsu, Ryan;Barakos, Jerome
背景：我们之前在一个小样本中证明，与非酒精对照组相比，在接受治疗的幼稚酒精依赖(TXN)男性中，与年龄相关的灰质萎缩程度更大，但无法区分年龄和终生饮酒时间(这两项高度相关)对此的影响。在目前的研究中，我们已经将样本量增加了四倍，并将其扩大到包括男性和女性在内，试图复制和扩展先前的发现，并区分年龄和饮酒对这一现象的贡献。方法：在当前的研究中，我们检测了18至50岁的TXN(84例)与年龄和性别可比的对照组(67例)的皮质灰质体积。我们使用了一种新的区域或兴趣分析方法，该方法解释了个体之间脑沟和脑回折叠的差异(Fein等人，2009a)。结果：我们发现TXN组与对照组相比，与年龄相关的灰质萎缩更大。偏相关分析表明，这种影响是年龄的函数，而不是终生酒精负担的函数。结论：这些发现的意义在于它们有助于我们了解不同酒精者亚群之间的差异，以及它们对全国老龄化人口中酒精依赖发病率的影响。
Background: We previously demonstrated, in a small sample, steeper age-related gray matter shrinkage in treatment naive alcohol-dependent (TxN) men compared to nonalcoholic controls, but could not separate out the contributions of age and lifetime durations Of alcohol Use (WhiCh Were highly correlated) to this effect. In the current study, we have quadrupled the sample size and expanded it to include both men and women to try to replicate and extend the previous findings and to separate the contributions of age and alcohol use to the phenomenon.Methods: In the current Study, we examine cortical gray matter volumes in 18- to 50-year-old TxN (it = 84) versus age and gender comparable controls (n = 67). We Used a new Region or Interest Analysis method WhiCh accounts for differences in sulcal and gyral enfolding between individuals (Fein et al., 2009a).Results: We found greater age-related gray matter shrinkage in TxN than in controls. Partial correlation analysis showed that the effect Was a function of age and not lifetime alcohol burden.Conclusions: Implications of the findings are discussed in terms of their contribution toward our knowledge of differences between different subpopulations of alcoholics and in terms of their implications, for the morbidity of alcohol dependence in an aging national population.