The ontogeny of interstimulus interval (ISI) discrimination of the conditioned eyeblink response in rats
The ontogeny of interstimulus interval (ISI) discrimination of the conditioned eyeblink response in rats
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DOI：
10.1037/0735-7044.120.5.1057
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发表时间：
2006-10-01
影响因子：
1.9
通讯作者：
Stanton, Mark E.
中科院分区：
文献类型：
--
作者：
Brown, Kevin L.;Pagani, Jerome H.;Stanton, Mark E.
研究了不同持续时间和方式的条件刺激对大鼠眨眼条件反应（CR）的影响。实验1在出生后23-34天出现明显的刺激间期（ISI）辨别，ISI辨别组较短刺激间期对照组相比，长刺激间期识别组的CR峰潜伏期更早，CR幅值增强。实验2表明，ISI识别组对长CS的CR峰潜伏期提前和CR幅值增强是由于短CS与非条件刺激的关联配对所致。实验3显示，成人的ISI辨别能力相对于年轻被试有所提高，但ISI辨别组对长CS的CR振幅没有增强。小脑皮质成熟可能影响CR的发生时间。
Discrimination of the eyeblink conditioned response (CR) between conditioned stimuli (CSs) of different durations and modalities was examined across development in rats. Interstimulus interval (ISI) discrimination was evident at Postnatal Days 23-34 in Experiment 1, and earlier CR peak latencies and enhanced CR amplitudes were seen to the long CS in the ISI discrimination group relative to a control group receiving the short CS without reinforcement. Experiment 2 showed that early CR peak latencies and enhanced CR amplitudes to the long CS in the ISI discrimination group were due to associative pairing of the short CS and unconditioned stimulus. Experiment 3 demonstrated ISI discrimination in adults that was improved relative to younger subjects, but with no enhancement of CR amplitude to the long CS in the ISI discrimination group. Cerebellar cortical maturation may influence the ontogeny of CR timing.