Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1.
Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1.
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DOI：
10.1038/s43587-022-00312-x
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发表时间：
2022-12
期刊：
影响因子：
--
通讯作者：
Alic N
中科院分区：
文献类型：
--
作者：
Martínez Corrales G;Li M;Svermova T;Goncalves A;Voicu D;Dobson AJ;Southall TD;Alic N
一个短暂的，稳态的转录反应可以导致转录记忆，编程随后的转录输出。转录记忆在改变动物衰老方面具有巨大但未被认识到的潜力，因为动物在其一生中会遇到大量不同的刺激。本研究表明，仅在雌性果蝇成年早期激活一种进化上保守的、促进长寿的转录因子dFOXO，就足以改善它们在中年和晚年的健康和生存。这种受青少年限制的dFOXO激活导致脂肪体中染色质景观的持续变化，并需要染色质重塑者（如SWI/SNF和ISWI复合体）来规划健康和长寿。染色质重塑伴随着一个长期的转录程序，这与急性dFOXO激活期间观察到的转录程序不同，包括Xbp1的诱导。我们发现，Xbp1的晚年诱导足以降低晚年死亡率。我们的研究表明，转录记忆可以深刻地改变动物的衰老方式。
A transient, homeostatic transcriptional response can result in transcriptional memory, programming subsequent transcriptional outputs. Transcriptional memory has great but unappreciated potential to alter animal ageing as animals encounter a multitude of diverse stimuli throughout their lifespan. Here we show that activating an evolutionarily conserved, longevity-promoting transcription factor, dFOXO, solely in early adulthood of female fruit flies is sufficient to improve their subsequent health and survival in mid- and late life. This youth-restricted dFOXO activation causes persistent changes to chromatin landscape in the fat body and requires chromatin remodellers such as the SWI/SNF and ISWI complexes to program health and longevity. Chromatin remodelling is accompanied by a long-lasting transcriptional programme that is distinct from that observed during acute dFOXO activation and includes induction of Xbp1. We show that this later-life induction of Xbp1 is sufficient to curtail later-life mortality. Our study demonstrates that transcriptional memory can profoundly alter how animals age.
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影响因子：
2.5
作者：
Bheda P;Kirmizis A;Schneider R
通讯作者：
Schneider R
Foxo抑制糖饮食的寿命的营养编程。
影响因子：
8.8
作者：
Dobson AJ;Ezcurra M;Flanagan CE;Summerfield AC;Piper MDW;Gems D;Alic N
通讯作者：
Alic N
DOI：
10.1093/bioinformatics/btv562
发表时间：
2016-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Gel B;Díez-Villanueva A;Serra E;Buschbeck M;Peinado MA;Malinverni R
通讯作者：
Malinverni R
影响因子：
4.6
作者：
Doiguchi M;Nakagawa T;Imamura Y;Yoneda M;Higashi M;Kubota K;Yamashita S;Asahara H;Iida M;Fujii S;Ikura T;Liu Z;Nandu T;Kraus WL;Ueda H;Ito T
通讯作者：
Ito T
影响因子：
3.3
作者：
Bateman, Jack R.;Lee, Anne M.;Wu, C. -ting
通讯作者：
Wu, C. -ting