RENAL AUTOREGULATION - MODELS COMBINING TUBULOGLOMERULAR FEEDBACK AND MYOGENIC RESPONSE
RENAL AUTOREGULATION - MODELS COMBINING TUBULOGLOMERULAR FEEDBACK AND MYOGENIC RESPONSE
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DOI：
10.1152/ajprenal.1987.252.4.f768
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发表时间：
1987-04-01
影响因子：
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通讯作者：
OIEN, AH
中科院分区：
文献类型：
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作者：
AUKLAND, K;OIEN, AH
如前所述，在不同的动脉压下，肾血流量(RBF)和肾小球滤过率(GFR)的自动调节可能源于肌源性反应(MR)，以维持肾小球前血管段的壁张力。我们现在将MR与响应远端肾小管流量的肾小管球球反馈结合起来。该模型由A)肾小球前阻力和B)肾小球后阻力、C)肾小球滤过和D)肾小管系统组成。转化生长因子作用于大鼠和狗的肾小球前阻力，其参数模拟单个肾单位远端肾小管流速的反应，但不能解释实验观察到的RBF和GFR的自动调节。加入肾小球前MR可获得良好的自我调节。在这种组合中，转化生长因子主要在自我调节的较低范围内被激活。在动脉压降低时增加肾小球后阻力或增加肾小球滤过系数的机制会削弱RBF自动调节，而GFR自动调节仅略有改善。转化生长因子对肾小球前后阻力的同向调节似乎只有与肾小球前肌形成机制相结合时才能与良好的自我调节相兼容。
As shown previously, autoregulation of renal blood flow (RBF) and glomerular filtration rate (GFR) at varying arterial pressure may result from a myogenic response (MR) acting to maintain wall tension in each preglomerular vessel segment. We now combine MR with tubuloglomerular feedback (TGF) responding to distal tubular flow rate. The model consists of A) preglomerular and B) postglomerular resistances, C) glomerular filtration, and D) a tubular system. TGF acting on preglomerular resistance with parameters that mimic responses to single nephron distal tubular flow rate in rats and dogs failed to account for the autoregulation of RBF and GFR observed experimentally. Good autoregulation was obtained by adding preglomerular MR. In this combination TGF is activated mainly in the lower range of autoregulation. Addition of mechanisms that increase postglomerular resistance or increase the glomerular filtration coefficient at reduced arterial pressure impairs RBF autoregulation, whereas GFR autoregulation is only slightly improved. TGF regulation of pre-and postglomerular resistance in the same direction seems compatible with good autoregulation only when combined with a preglomerular myogenic mechanism.