The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation.
The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation.
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DOI：
10.1038/onc.2010.222
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发表时间：
2010-09-02
期刊：
影响因子：
8
通讯作者：
Aifantis, I.
中科院分区：
文献类型：
--
作者：
Crusio, K. M.;King, B.;Reavie, L. B.;Aifantis, I.
泛素-蛋白酶体系统 (UPS) 是一种多亚基途径，允许对蛋白质进行泛素修饰，并导致降解或其他非蛋白水解过程，例如运输或转录激活。鉴于其作为细胞稳态调节剂的作用，UPS 成员在包括癌症在内的多种疾病状态下频繁异常表达也就不足为奇了。本综述将重点关注 UPS 的一个成员 F-box 蛋白 Fbw7（也称为 Sel-10、Ago、hCDC4），并讨论 Fbw7 在发育和肿瘤发生背景下与其底物相互作用的机制。此外，还将研究该途径的拮抗剂以及当前和未来的 UPS 治疗方法。
The ubiquitin-proteasome system (UPS) is a multi-subunit pathway that allows for ubiquitin modification of proteins and leads to either degradation or other non-proteolytic processes such as trafficking or transcriptional activation. Given its role as a regulator of cellular homeostasis it is not surprising that members of the UPS are frequently aberrantly expressed in a number of disease states including cancer. This review will focus on one member of the UPS, the F-box protein, Fbw7 (also known as Sel-10, Ago, hCDC4) and mechanisms by which Fbw7 interacts with its substrates in the context of development and tumorigenesis will be discussed. In addition, antagonists of this pathway as well as current and future therapeutics for the UPS will be examined.
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影响因子：
64.5
作者：
Bassermann, Florian;Frescas, David;Guardavaccaro, Daniele;Busino, Luca;Peschiaroli, Angelo;Pagano, Michele
通讯作者：
Pagano, Michele
影响因子：
16
作者：
Hao, Bing;Oehlmann, Stephanie;Pavletich, Nikola P.
通讯作者：
Pavletich, Nikola P.
DOI：
10.1182/asheducation-2009.1.353
发表时间：
2009-01-01
期刊：
Hematology. American Society of Hematology. Education Program
影响因子：
--
作者：
Ferrando, Adolfo A
通讯作者：
Ferrando, Adolfo A
影响因子：
8
作者：
Finkin, S.;Aylon, Y.;Shaulian, E.
通讯作者：
Shaulian, E.
影响因子：
50.3
作者：
Loeb, KR;Kostner, H;Roberts, JM
通讯作者：
Roberts, JM