Facile Synthesis of Cyclohexanediones and Dialkylresorcinols – Bioactive Natural Products from Entomopathogenic Bacteria
Facile Synthesis of Cyclohexanediones and Dialkylresorcinols – Bioactive Natural Products from Entomopathogenic Bacteria
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DOI：
10.1002/ejoc.201403346
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发表时间：
2014-12
影响因子：
2.8
通讯作者：
Max Kronenwerth;Christina Dauth;M. Kaiser;I. Pemberton;H. Bode
中科院分区：
文献类型：
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作者：
Max Kronenwerth;Christina Dauth;M. Kaiser;I. Pemberton;H. Bode
开发了最近鉴定的、广泛存在的细菌天然产物二烷基间苯二酚类和环己二酮类的合成。合成途径与生物合成途径相似，因为环己二酮环的形成由两部分产生，如在发光杆菌中鉴定的多官能异丙基芪的合成所例示。这些化合物的测试显示了对布氏锥虫罗得西亚和T. cruzi，昏睡病和恰加斯病的病原体，
A synthesis for the recently identified, widespread bacterial natural product classes of dialkylresorcinols and cyclohexanediones was developed. The synthesis route is similar to the biosynthesis route in that the formation of the cyclohexanedione ring results from two parts, as exemplified by the synthesis of the multifunctional isopropylstilbenes identified in Photorhabdus luminescens. Testing of these compounds revealed good bioactivity against Trypanosoma brucei rhodesiense and T. cruzi, the causative agents of sleeping sickness and Chagas disease, respectively