Multiple Deeply Divergent Denisovan Ancestries in Papuans
Multiple Deeply Divergent Denisovan Ancestries in Papuans
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DOI：
10.1016/j.cell.2019.02.035
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发表时间：
2019-05-02
期刊：
影响因子：
64.5
通讯作者：
Cox, Murray P.
中科院分区：
文献类型：
--
作者：
Jacobs, Guy S.;Hudjashov, Georgi;Cox, Murray P.
基因组序列是已知的两个古老的人类-尼安德特人和丹尼索瓦人-杂交与解剖学上的现代人类，因为他们分散出非洲。我们在东南亚岛屿和新几内亚的14个岛屿群的161个新基因组中确定了高置信度的古老单倍型，并发现了与单一渐渗丹尼索瓦人起源不一致的大片DNA。相反，现代巴布亚人携带着数百种基因变体，来自两个截然不同的丹尼索瓦血统，这两个血统在35万年前分离。这些谱系之间的空间和时间结构表明，从这些丹尼索瓦人群体之一的渗入主要发生在华莱士线以东，并一直持续到更新世末期。第三个丹尼索瓦血统出现在现代东亚人中。这种区域性的镶嵌表明古代接触相当复杂，现代人与多个丹尼索瓦人群体杂交，这些群体在进化的时间里在地理上相互隔离。
Genome sequences are known for two archaic hominins-Neanderthals and Denisovans-which interbred with anatomically modern humans as they dispersed out of Africa. We identified high-confidence archaic haplotypes in 161 new genomes spanning 14 island groups in Island Southeast Asia and New Guinea and found large stretches of DNA that are inconsistent with a single introgressing Denisovan origin. Instead, modern Papuans carry hundreds of gene variants from two deeply divergent Denisovan lineages that separated over 350 thousand years ago. Spatial and temporal structure among these lineages suggest that introgression from one of these Denisovan groups predominantly took place east of the Wallace line and continued until near the end of the Pleistocene. A third Denisovan lineage occurs in modern East Asians. This regional mosaic suggests considerable complexity in archaic contact, with modern humans interbreeding with multiple Denisovan groups that were geographically isolated from each other over deep evolutionary time.