Identification of Tyr58 as the proton donor in the aspartate-α-decarboxylase reaction

Identification of Tyr58 as the proton donor in the aspartate-α-decarboxylase reaction
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DOI:
10.1039/b106090m
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发表时间:
2001-09-21
影响因子:
4.9
通讯作者:
Abell, C
Abell, C
中科院分区:
化学2区
文献类型:
--
作者:
Saldanha, SA;Birch, LM;Abell, C

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The decarboxylation of L-aspartate by E. coli L-aspartate-alpha -decarboxylase (ADC) is shown to occur with retention of configuration; analysis of the protein structure identifies Tyr58 as the proton donor in the decarboxylation mechanism.