Melioidosis in a rural community of Western Province, Papua New Guinea
Melioidosis in a rural community of Western Province, Papua New Guinea
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DOI：
10.1016/j.trstmh.2007.02.024
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发表时间：
2007-08-01
影响因子：
2.2
通讯作者：
Hirst, R. G.
中科院分区：
文献类型：
--
作者：
Warner, J. M.;Pelowa, D. B.;Hirst, R. G.
在巴布亚新几内亚西部省巴里莫地区进行了一项前瞻性研究，以确定类鼻疽病的意义。1998年，在建立了实验室程序并增加了Tocal。临床上的。意识到，这种疾病在1.8%(95%CI 0.37-5.1%)的个人中发现，出现对标准治疗无效的发热。临床发病率为20.0/100000(95%CI 12.2~30.9)。培养确诊病例的中位年龄为9.5岁(四分位数范围8.3-14.8岁)。该地区747名社区儿童血清流行率为8.2%(95%CI 6.2-10.4%)。大多数人在雨季表现出一种对标准治疗无效的发热性疾病，有时还会模仿结核病。部分家系聚集性明显。所有细菌性类鼻疽病患者全部死亡，但现有的氯霉素、复方新诺明或多西环素等传统疗法使6名亚急性/局限性类鼻疽患者存活并治愈。需要进行进一步的研究，以确定当地的流行病学和为什么儿童似乎特别危险，以及确定巴布亚新几内亚类鼻疽病的真实程度。(C)2007年皇家热带医学和卫生学会。爱思唯尔有限公司出版。保留所有权利。
A prospective study was conducted to determine the significance of melioidosis in the Balimo district of Western Province, Papua New Guinea. During 1998, after the establishment of laboratory procedures and increasing tocal. clinical. awareness, the disease was found in 1.8% (95% Cl 0.37-5.1%) of individuals presenting with fever refractory to standard treatment. The clinical incidence was 20.0 per 100000 population (95% Cl 12.2-30.9). The median age of culture-confirmed cases was 9.5 years (interquartile range 8.3-14.8 years). The sero-prevalence of 747 community children in the region tested was 8.2% (95% Cl 6.2-10.4%). Most individuals presented during the rainy season with a febrile disease refractory to standard treatment, sometimes mimicking tuberculosis. Some family clustering was apparent. AIL patients with bacteraemic melioidosis died, but treatment with the available conventional therapies of chloramphenicol, co-trimoxazole or doxycycline resulted in survival and cure in six patients with subacute/localised melioidosis. Further studies are needed to ascertain the local epidemiology and why children appear particularly at risk, as well as to establish the true extent of melioidosis in Papua New Guinea. (c) 2007 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.