Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative resection of gastric cancer
Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative resection of gastric cancer
复制标题
DOI：
10.1016/j.amjsurg.2011.10.015
复制
发表时间：
2012-09-01
影响因子：
3
通讯作者：
McMillan, Donald C.
中科院分区：
文献类型：
--
作者：
Dutta, Sumanta;Crumley, Andrew B. C.;McMillan, Donald C.
背景：越来越多的证据表明，患者相关的全身炎症反应是一个强有力的预后因素。本研究的目的是比较所选的全身炎症反应的标志物在胃癌切除术患者的预后价值。方法：120例胃癌切除术患者，除了肿瘤相关因素的各种全身炎症标志物的测量。计算改良格拉斯哥预后评分（mGPS）、中性粒细胞/淋巴细胞比率、血小板/淋巴细胞比率和转移淋巴结比率。（风险比，2.29%; 95%置信区间，1.57%-3.33%; P < .001）和mGPS（风险比，2.23%; 95%可信区间，1.40%-3.54%; P = 0.001）与胃癌患者的癌症特异性生存率独立相关。mGPS的增加与较高的中性粒细胞/淋巴细胞比率（P <0.05）和较差的生存率（P <0.001）相关。结论：本研究表明，与胃癌切除术患者全身炎症反应的细胞成分相比，mGPS是一种急性期基于蛋白质的预后评分，是一种上级的癌症生存预测因子。(C)2012 Elsevier Inc. All rights reserved.
BACKGROUND: There is increasing evidence that the patient-related systemic inflammatory response is a powerful prognostic factor. The aim of the present study was to compare the prognostic value of selected markers of the systemic inflammatory response in patients undergoing resection of gastric cancer.METHODS: One hundred twenty patients undergoing resection of gastric cancer, had measurements of various systemic inflammatory markers in addition to tumor-related factors. From these, the modified Glasgow Prognostic Score (mGPS), neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and metastatic lymph node ratio were calculated.RESULTS: On multivariate analysis, only the ratio of positive to total lymph nodes (hazard ratio, 2.29%; 95% confidence interval, 1.57%-3.33%; P < .001) and the mGPS (hazard ratio, 2.23%; 95% confidence interval, 1.40%-3.54%; P = .001) were independently associated with cancer-specific survival in patients with gastric cancer. An increase in the mGPS was associated with a higher neutrophil/lymphocyte ratio (P < .05) and poorer survival (P < .001).CONCLUSIONS: The present study indicates that the mGPS, an acute-phase, protein-based prognostic score, is a superior predictor of cancer survival compared with the cellular components of the systemic inflammatory response in patients undergoing resection of gastric cancer. (C) 2012 Elsevier Inc. All rights reserved.