Dynamic changes in the medial temporal lobe during incidental learning of object-location associations.
Dynamic changes in the medial temporal lobe during incidental learning of object-location associations.
复制标题
物体位置关联的偶然学习过程中内侧颞叶的动态变化。
DOI：
10.1093/cercor/bhr151
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Hanson,StephenJosé
中科院分区：
文献类型：
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作者：
Manelis,Anna;Reder,LynneM;Hanson,StephenJosé
内侧颞叶(MTL)在联想记忆编码中的作用一直是许多记忆实验的焦点。然而，令人惊讶的是，关于不同的MTL亚区(杏仁核、海马体[HPC]、海马旁[PHC]、咽周皮质[PRC]和颞极皮质[TPC])的贡献是否在关联编码的多个呈现中转移的研究令人惊讶地少。我们使用事件相关功能磁共振成像和多体素模式分类分析来研究这个问题。受试者执行视觉搜索任务，随着练习的进行，定位位置在试验中保持不变的物体的速度变得更快。分类分析表明，当从试验到试验的速度最快时，任务的早期就涉及右侧HPC和杏仁核。同样的分析表明，当加速最小时，右侧PRC和TPC在学习中较晚。这些结果表明，联想编码依赖于MTL中复杂的神经活动模式，而不能通过学习过程中简单的血氧水平依赖信号的增加或减少来表达。在编码物体-位置关联时，MTL亚区的参与取决于学习阶段的性质。右侧HPC和杏仁核支持物体和位置信息的主动整合，而当物体和空间表征被合并为单一表征时，右侧PRC和TPC参与其中。
The role of the medial temporal lobe (MTL) in associative memory encoding has been the focus of many memory experiments. However, there has been surprisingly little investigation of whether the contributions of different MTL subregions (amygdala, hippocampus [HPC], parahippocampal [PHc], perirhinal cortex [PRc], and temporal polar cortex [TPc]) shift across multiple presentations during associative encoding. We examined this issue using event-related functional magnetic resonance imaging and a multivoxel pattern classification analysis. Subjects performed a visual search task, becoming faster with practice to locate objects whose locations were held constant across trials. The classification analysis implicated right HPC and amygdala early in the task when the speed-up from trial to trial was greatest. The same analysis implicated right PRc and TPc late in learning when speed-up was minimal. These results suggest that associative encoding relies on complex patterns of neural activity in MTL that cannot be expressed by simple increases or decreases of blood oxygenation level—dependent signal during learning. Involvement of MTL subregions during encoding of object–location associations depends on the nature of the learning phase. Right HPC and amygdala support active integration of object and location information, while right PRc and TPc are involved when object and spatial representations become unitized into a single representation.