Incidence of diabetes and gout in hypertensive patients during 8 years of follow-up
Incidence of diabetes and gout in hypertensive patients during 8 years of follow-up
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DOI：
10.1038/sj.jhh.1000496
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发表时间：
1997-09-01
影响因子：
2.7
通讯作者：
Bulpitt, CJ
中科院分区：
文献类型：
--
作者：
Grodzicki, T;Palmer, A;Bulpitt, CJ
高血压已被证明与糖尿病和痛风等代谢紊乱密切相关，本研究的目的是确定高血压患者及其年龄匹配的对照组中这两种疾病的发病率，并评估与利尿剂治疗相关的风险，结果参考了来自全科医学高血压研究组的2295名高血压患者和2280名对照者的数据库，这些人接受了高血压筛查，对1190例高血压患者和938例正常对照者进行平均8年的随访。糖尿病和痛风的诊断由全科医生进行。经过8年的随访，5.0%的高血压患者和1.5%的血压正常者被诊断为糖尿病。痛风的诊断分别为3.1%和0.9%。此外，糖尿病的发生率在高血压男性和女性中更高，有利尿剂治疗和无利尿剂治疗（分别为：男性使用利尿剂：相对风险（RR）= 2.74，95%置信区间（CI）：0.99，7.5;男性未使用利尿剂：RR = 2.25，95% CI：1.0，5.3;女性RR = 4.03，95% CI：与年龄匹配的对照组相比，高血压男性患者在接受和未接受利尿剂治疗的情况下证实痛风过量（RR = 6.25（95% CI：2.4，16.7）vs 3.93（95% CI：1.6，9.7））。
Hypertension has been shown to be closely associated with metabolic disorders such as diabetes mellitus and gout, The aim of this study was to establish the incidence of both these diseases in hypertensive patients and their age-matched controls and to assess the risk associated with diuretic treatment, The results refer to the data base of 2295 hypertensive and 2280 controls from the General Practice Hypertension Study Group who were screened for hypertension, The rescreened hypertensive subjects (n=1190) and their controls (n = 938) were followed for an average of 8 years, The diagnosis of diabetes and gout was made by their general practitioners. After 8 years of follow-up, diabetes mellitus was diagnosed in 5.0% of hypertensive and 1.5% normotensive subjects. The diagnosis of gout was made in 3.1% and 0.9%, respectively. Moreover, diabetes mellitus occurred more frequently in both hypertensive men and women, with diuretic treatment and without (respectively, men given diuretic: relative risk (RR) = 2.74, 95% confidence interval (CI): 0.99, 7.5; and men not given diuretic: RR = 2.25, 95% CI: 1.0, 5.3: women RR = 4.03 95% CI: 1.5, 10.8, and RR = 3.47, 95% CI: 1.4, 8.9) in comparison with their age-matched controls, For gout the excess was confirmed in hypertensive men with and without diuretic treatment (RR = 6.25 (95% CI: 2.4, 16.7) vs 3.93 (95% CI: 1.6, 9.7)).