Evolutionary conservation of meiotic DSB proteins: more than just Spo11
Evolutionary conservation of meiotic DSB proteins: more than just Spo11
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DOI：
10.1101/gad.1944710
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发表时间：
2010-06-15
影响因子：
10.5
通讯作者：
Jasin, Maria
中科院分区：
文献类型：
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作者：
Cole, Francesca;Keeney, Scott;Jasin, Maria
减数分裂重组由Spo 11蛋白产生的程序性DNA双链断裂（DSB）启动。在芽殖酵母中，DSB的形成也需要其他五种减数分裂特异性蛋白质，但是，除了罕见的例外，在其他物种中尚未鉴定出直系同源物。在这个问题的基因与发展，库马尔和同事（pp。1266-1280）使用了一种新的基因组方法来鉴定跨多个进化枝的这些蛋白质中的两种，并证实其中之一MEI 4是小鼠中的功能性直系同源物。
Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) generated by the Spo11 protein. In budding yeast, five other meiotic-specific proteins are also required for DSB formation, but, with rare exception, orthologs had not been identified in other species. In this issue of Genes & Development, Kumar and colleagues (pp. 1266-1280) used a phylogenomic approach to identify two of these proteins across multiple clades, and confirmed that one of these, MEI4, is a functional ortholog in mouse.