What can ADHD without comorbidity teach us about comorbidity?
What can ADHD without comorbidity teach us about comorbidity?
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DOI：
10.1016/j.ridd.2011.09.024
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发表时间：
2012-03-01
影响因子：
3.1
通讯作者：
Elia, Josephine
中科院分区：
文献类型：
--
作者：
Takeda, Toshinobu;Ambrosini, Paul J.;Elia, Josephine
ADHD 中的神经精神合并症很常见，会造成损害，但人们对此知之甚少。在本报告中，对共病和无共病 ADHD 受试者的特征进行了调查，试图找出可能促进我们对危险因素的理解的差异。在临床转诊的 449 名青少年（6-18 岁）ADHD 队列中，比较了无共病 ADHD 受试者和患有内化和外化障碍的 ADHD 受试者的年龄、性别、IQ SES 和 ADHD 症状。还进行了逻辑回归分析，以调查合并症与父母精神状况之间的关系。无合并症的 ADHD 年龄范围较小，ADHD + 内化障碍年龄范围较大。 ADHD 共病组和无共病组的 IQ 或 SES 没有显着差异。患有内化障碍的多动症与父亲的精神疾病有显着更大的关联。按年龄、性别、智商和社会经济地位进行匹配后，外化障碍ADHD的ADHD总分、多动/冲动评分和等待轮到困难单项评分显着高于无合并症ADHD和内化障碍ADHD。年龄范围较大、ADHD症状严重程度和父母精神病理学可能是合并症的危险因素。 (C) 2011 Elsevier Ltd. 保留所有权利。
Neuropsychiatric comorbidity in ADHD is frequent, impairing and poorly understood. In this report, characteristics of comorbid and comorbid-free ADHD subjects are investigated in an attempt to identify differences that could potentially advance our understanding of risk factors.In a clinically-referred ADHD cohort of 449 youths (ages 6-18), age, gender, IQ SES and ADHD symptoms were compared among ADHD comorbid free subjects and ADHD with internalizing and externalizing disorders. Logistic regression analyses were also carried out to investigate the relationship between comorbidity and parental psychiatric status.Age range was younger in the ADHD without comorbidity and older in ADHD + internalizing disorders. No significant difference in IQ or SES was found among ADHD comorbid and comorbid-free groups. ADHD with internalizing disorder has a significantly greater association with paternal psychiatric conditions. After matching by age, gender, IQ and SES, ADHD with externalizing disorders had significantly higher total ADHD, hyperactivity/impulsivity score and single item score of difficulty awaiting turn than ADHD without comorbidity and ADHD with internalizing disorders.Older age ranges, ADHD symptom severity and parental psychopathology may be risk factors for comorbidity. (C) 2011 Elsevier Ltd. All rights reserved.