Male and couple fertility impairment due to HPV-DNA sperm infection: update on molecular mechanism and clinical impact--systematic review.
Male and couple fertility impairment due to HPV-DNA sperm infection: update on molecular mechanism and clinical impact--systematic review.
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DOI：
10.1155/2014/230263
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发表时间：
2014
影响因子：
--
通讯作者：
Nardelli GB
中科院分区：
文献类型：
--
作者：
Gizzo S;Ferrari B;Noventa M;Ferrari E;Patrelli TS;Gangemi M;Nardelli GB
最近的证据表明，人类乳头瘤病毒(HPV)精子感染可能是导致男性和夫妇不育的原因之一。它在人类受孕和早期妊娠发育的不同阶段通过不同的机制发挥作用。我们进行了一项系统的回顾，以评估HPV精液感染在男性和夫妇不育症中的作用。对现有和合格数据的分析不允许我们提供关于HPV感染对生育能力的临床影响的明确证据，尽管精子参数受损是最广泛认识的影响。关于生物分子的影响，现有的数据往往是相互矛盾的。需要更多的研究来确定HPV精子感染在临床实践中的作用。绝大多数证据是通过体外研究获得的，这一事实限制了HPVDNA精子感染的临床治疗。了解HPV-DNA精液感染的生物学意义可以让我们解释大多数特发性男性和夫妇不育的原因，从而更好地管理不育男性，并在ART周期之前更好地保存精子库。
Recent evidences identify Human Papillomavirus (HPV) sperm infection as a possible cause of male and couple infertility. It acts through different mechanisms at various steps of human conception and early gestational development. We performed a systematic review to assess the role of HPV semen infection on male and couple infertility. Analysis of available and eligible data does not permit us to fund clear evidences about clinical impact of HPV infection on fertility, although sperm parameters impairment is the most widely recognized effect. Regarding biomolecular implications, the available data are often conflicting. More studies are required to define the role of HPV sperm infection in clinical practice. The great majority of evidences are obtained by in vitro studies and this fact represents a limitation for the clinical management of HPVDNA sperm infection. Understanding the biological significance of HPV-DNA semen infection could permit us to explain most of the idiopathic male and couple infertility, leading to a better management of infertile men and a better timing for sperm banking storage before ART cycles.