Ganglioside GD3 enhances adherence of botulinum and tetanus neurotoxins to bovine brain synapsin I.
Ganglioside GD3 enhances adherence of botulinum and tetanus neurotoxins to bovine brain synapsin I.
复制标题
神经节苷脂 GD3 增强肉毒杆菌和破伤风神经毒素对牛脑突触蛋白 I 的粘附。
DOI：
10.1016/0304-3940(93)90253-h
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发表时间：
1993
影响因子：
2.5
通讯作者：
Ringler,NJ
中科院分区：
文献类型：
--
作者：
Schengrund,CL;DasGupta,BR;Ringler,NJ
Tetanus toxin (TTx) and botulinum toxin serotype A (BTxA), preincubated with trisialoganglioside GT1b, adhere to proteins present on blots of bovine synaptosomal proteins. Differential solubilization and ammonium sulfate fractionation provided material enriched in two proteins that appeared to be adhered to most strongly by the labeled neurotoxins. After excision of the appropriate bands from blots of electrophoretically separated proteins, N-terminal amino acid sequence analysis permitted identification of the proteins as synapsins Ia and Ib. Comparison of the effectiveness of different gangliosides at enhancing adherence of the neurotoxins to blots of synapsins Ia and Ib indicated that GD3 was most effective.
