Regional differences in relationships between apparent white matter integrity, cognition and mood in patients with ischemic stroke.
Regional differences in relationships between apparent white matter integrity, cognition and mood in patients with ischemic stroke.
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缺血性中风患者表观白质完整性、认知和情绪之间关系的区域差异。
DOI：
10.1080/13803390903427406
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发表时间：
2010
影响因子：
2.2
通讯作者：
Gorelick,Philip
中科院分区：
文献类型：
--
作者：
Williamson,John;Nyenhuis,David;Stebbins,GlennT;Lamb,Damon;Simkus,Vaidas;Sripathirathan,Kumar;Wang,Changsheng;deToledo-Morrell,Leyla;Gorelick,Philip
白色物质改变是脑血管病行为改变的一个潜在病因。全脑弥散张量成像-分数各向异性（DTI-FA）作为一种测量表观白色物质完整性的方法，与脑血管病患者的认知功能有关。然而，白色物质的变化并不均匀，其影响也不均匀。我们在缺血性中风样本中研究了DTI-FA的区域差异与认知和情绪之间的关系。参与者为108例卒中后3-6个月的患者。工作记忆，基本注意力，回忆，语言，视觉空间，心理和编码技能，和情绪进行了评估，通过神经心理学评估。采用GE 1.5T磁共振成像系统进行DTI扫描。分数各向异性（FA）计算额，颞，枕，顶叶区域使用自动面具。额叶和顶叶脂肪酸更强烈和一贯相关的认知和情绪评分比FA值从整个大脑或颞叶或枕叶区域。本研究有助于我们了解脑血管病认知和情绪障碍的病因。
White matter changes are one potential etiology of behavioral changes in cerebrovascular disease. Whole brain diffusion tensor imaging–fractional anisotropy (DTI-FA) as a measure of apparent white matter integrity is related to cognitive function in cerebrovascular disease. However, white matter changes are not uniform, nor are their effects. We examine the relationship between regional differences in DTI-FA and cognition and mood in an ischemic-stroke sample. Participants were 108 patients, 3–6 months post stroke. Working memory, basic attention, recall, language, visuo-spatial, psychomotor, and encoding skills, and mood were assessed via neuropsychological evaluation. DTI scans were performed on a 1.5T GE magnetic resonance imaging (MRI) system. Fractional anisotropy (FA) was calculated for frontal, temporal, occipital, and parietal regions using automated masks. Frontal and parietal FAs were more strongly and consistently related to cognitive and mood scores than were FA values from whole brain or temporal or occipital regions. This research contributes to our understanding of the etiology of cognitive and mood deficits in cerebrovascular disease.