New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: A 25-year follow-up study
New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: A 25-year follow-up study
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DOI：
10.1016/s0021-9150(97)00106-8
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发表时间：
1997-07-25
期刊：
影响因子：
5.3
通讯作者：
Wilson, PWF
中科院分区：
文献类型：
--
作者：
Kauppila, LI;Polak, JF;Wilson, PWF
本研究的目的是评估不透射线腰主动脉钙化的位置、严重程度和进展，并评价基于人群队列的腰椎钙化汇总评分的效用。对617例心脏病研究参与者的腰椎侧位片进行了分析，以确定第一至第四腰椎对应区域是否存在腹主动脉壁钙化。对每个腰椎节段的前和后主动脉钙化的严重程度分别采用0-3量表进行分级，并对结果进行总结，得出4种不同的复合评分：（1）受累节段评分（范围0-4）;（2）前部和后部受累评分（范围0-8）;和（3）前后严重程度评分（范围0-24）。主动脉钙化的患病率在基线时男性为37%，女性为27%，在25年后的随访检查中两种性别均为86%。在随访期间，受影响节段的平均评分从男性的0.7增加到（女性0.5）至2.7（女性2.8），前部和后部受累评分的平均值为1.2（女性0.8）（性别差异P = 0.012），前后严重程度评分的平均值从1.5（女性1.3）增加到9.3（女性10.3）。前后位严重程度评分比其他综合评分稍有优势，并且评分者间类内相关性最高。总之，可以对腰主动脉钙化进行分级，复合汇总评分具有重现性。这项技术似乎提供了一个简单的，低成本的亚临床血管疾病的评估。(C)1997 Elsevier Science爱尔兰有限公司
The purpose of the present study was to assess the location, severity and progression of radiopaque lumbar aortic calcifications and to evaluate the utility of summary scores of lumbar calcification in a population-based cohort. Lateral lumbar films, obtained in 617 Framingham heart study participants, were analysed for the presence of abdominal aortic wall calcification in the region corresponding to the first through fourth lumbar vertebrae. The severity of the anterior and posterior aortic calcification were graded individually on a 0-3 scale for each lumbar segment and the results were summarized to develop four different composite scores: (1) affected segments score (range 0-4); (2) anterior and posterior affected score (range 0-8); and (3) antero-posterior severity score (range 0-24). The prevalence of aortic calcification was 37% in men and 27% in women at baseline and 86% in both genders al the follow-up exam 25 years later. During the follow-up interval, the mean of the affected segments score increased from 0.7 in men (0.5 in women) to 2.7 (2.8 in women), the mean of the anterior and posterior affected score from 1.2 (0.8 in women) (P = 0.012 for difference between genders) and the mean of the antero-posterior severity score increased from 1.5 (1.3 in women) to 9.3 (10.3 in women). The antero-posterior severity score offered a slight advantage over other composite scores and had the highest inter-rater intra-class correlations. In summary, lumbar aortic calcification can be graded and composite summary scores are reproducible. This technique appears to provide a simple, low cost assessment of subclinical vascular disease. (C) 1997 Elsevier Science Ireland Ltd.