Computing an organism: on the interface between informatic and dynamic processes
Computing an organism: on the interface between informatic and dynamic processes
复制标题
DOI：
10.1016/s0303-2647(01)00178-2
复制
发表时间：
2002-01-01
期刊：
影响因子：
1.6
通讯作者：
Hogeweg, P
中科院分区：
文献类型：
--
作者：
Hogeweg, P
在生物信息处理中，不同空间和时间尺度上的过程之间的相互作用的重要性是Michael Conrad的工作中反复出现的主题（BioSystems，1995：35，157-160; BioSystems，1999：52，99-100）。在本文中，我提出了一些明确的计算模型，旨在捕捉和利用这种多级过程的一些基本特征的结果。在模型的制定，我试图尽量减少层次间的相互作用的明确定义，同时提供这种相互作用的发展的可能性。正如康拉德经常争论的那样，层间交互限制了可编程性。事实上，我们使用进化过程来推导特定的模型。我们研究形态发生。我们发现，细胞粘附和细胞分化之间的相互作用提供了有趣的机制形态发生。我们还表明，相互作用可以减少和增强小的随机波动。我们发现，不平等的细胞分裂在早期胚胎发育减少个体间的变化，从同一个“基因组”的语素。我们的研究结果表明，在进化过程中，水平之间的相互作用被利用，同时减少，以给予一定的优先继承的信息。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
The importance of interactions between processes at diverse space and time scales in biological information processing is a recurrent theme in the work of Michael Conrad (BioSystems, 1995: 35, 157-160; BioSystems, 1999: 52, 99-100). In this paper I present some results of explicit computational models that aim to capture and exploit some of the essential features of such multi-level processes. In the model formulation, I try to minimize the explicit definition of inter-level interactions, while providing the possibility of such interactions to develop. As often argued by Conrad inter-level interactions limit programmability. Indeed, we use an evolutionary process to derive the specific models. We study morphogenesis. We show that the interplay between cell adhesion and cell differentiation provides interesting mechanisms for morphogenesis. We also show that the interplay can both reduce and enhance small random fluctuations. We show that unequal cell cleavage in the early embryo-genesis reduces inter-individual variation of the morphemes developed from the same 'genome'. Our results suggest that, during evolution, the interplay between levels is exploited while it is at the same time reduced so as to give a certain primacy to inherited information. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.