New cytotoxic sesquiterpenes from the gorgonian Isis hippuris.
New cytotoxic sesquiterpenes from the gorgonian Isis hippuris.
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DOI：
10.1021/np000271n
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发表时间：
2000-10
影响因子：
5.1
通讯作者：
J. Sheu;K. Hung;Gueyhorng Wang;C. Duh
中科院分区：
文献类型：
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作者：
J. Sheu;K. Hung;Gueyhorng Wang;C. Duh
从柳珊瑚Isis hippuris中分离得到5个新的辛二萜烷型倍半萜：辛二萜醇A（1），辛二萜醇B（2），辛二萜酮（3），辛二萜醇A乙酸酯（4），辛二萜醇B乙酸酯（5），沿着已知的倍半萜辛二萜酸（6）。通过光谱和化学方法确定了这些代谢产物的结构。发现Metabolic 1和3-5对P-388、A549和HT-29癌细胞系表现出有效的细胞毒性。
Five new suberosane sesquiterpenes, suberosenol A (1), suberosenol B (2), suberosanone (3), suberosenol A acetate (4), and suberosenol B acetate (5), along with the known sesquiterpene subergorgic acid (6), have been isolated from the gorgonian Isis hippuris. The structures of these metabolites were established by spectroscopic and chemical methods. Metabolites 1 and 3-5 were found to exhibit potent cytotoxicity toward P-388, A549, and HT-29 cancer cell lines.