A distributed left hemisphere network active during planning of everyday tool use skills
A distributed left hemisphere network active during planning of everyday tool use skills
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DOI：
10.1093/cercor/bhh169
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发表时间：
2005-06-01
期刊：
影响因子：
3.7
通讯作者：
Grafton, ST
中科院分区：
文献类型：
--
作者：
Johnson-Frey, SH;Newman-Norlund, R;Grafton, ST
确定行动计划和/或执行所涉及的机制之间的关系对于理解熟练行为（包括工具使用）的神经基础至关重要。在这里，我们报告了两项针对健康惯用右手的成年人的功能磁共振成像研究的结果，其中使用事件相关的设计来区分参与计划的区域（即识别、检索和准备与熟悉的工具使用相关的动作）与用惯用右手（实验1）和非惯用左手（实验2）执行工具使用手势的区域。对于任一肢体，规划工具使用动作都会激活左大脑半球的分布式网络，包括：（i）后上颞沟，以及中颞回和上颞回的近端区域； (ii) 下额叶和腹侧运动前皮层； (iii) 两个不同的顶叶区域，一个位于前缘上回 (SMG)，另一个位于后 SMG 和角回； (iv) 背外侧前额皮质 (DLFPC)。除了左 DLFPC 之外，左顶叶、额叶和颞叶皮层的相邻和部分重叠的子区域也在动作执行过程中参与。我们认为，这种左偏网络构成了有意义的技能所依赖的语义和运动表征相互作用的神经基础。
Determining the relationship between mechanisms involved in action planning and/or execution is critical to understanding the neural bases of skilled behaviors, including tool use. Here we report findings from two fMRI studies of healthy, right-handed adults in which an event-related design was used to distinguish regions involved in planning (i.e. identifying, retrieving and preparing actions associated with a familiar tools' uses) versus executing tool use gestures with the dominant right (experiment 1) and non-dominant left (experiment 2) hands. For either limb, planning tool use actions activates a distributed network in the left cerebral hemisphere consisting of: (i) posterior superior temporal sulcus, along with proximal regions of the middle and superior temporal gyri; (ii) inferior frontal and ventral premotor cortices; (iii) two distinct parietal areas, one located in the anterior supramarginal gyrus (SMG) and another in posterior SMG and angular gyrus; and (iv) dorsolateral prefrontal cortex (DLFPC). With the exception of left DLFPC, adjacent and partially overlapping sub-regions of left parietal, frontal and temporal cortex are also engaged during action execution. We suggest that this left lateralized network constitutes a neural substrate for the interaction of semantic and motoric representations upon which meaningful skills depend.