Bacterial flora of the lower respiratory tract in children with bronchial asthma
Bacterial flora of the lower respiratory tract in children with bronchial asthma
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DOI：
10.1080/080352599750030310
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发表时间：
1999-11-01
期刊：
影响因子：
3.8
通讯作者：
Grimfeld, A
中科院分区：
文献类型：
--
作者：
Fayon, M;Just, J;Grimfeld, A
这项回顾性研究的目的是（i）确定儿童纤维镜检查期间获得的下呼吸道样本的污染风险； (ii) 确定选定的一组细菌感染高危哮喘儿童的下呼吸道细菌菌群的发病率和概况； (iii) 确定此类发现的风险标记。在 29 名哮喘儿童中，对从上呼吸道和下呼吸道获取的标本进行细菌培养的比较表明，只有 3.4%（1/29）的病例可能存在污染。对通过可弯曲支气管镜检查获得的细菌样本的结果进行了分析，该样本对另外 273 名经连续调查的医生诊断为哮喘的儿童进行了分析。如果患者患有严重的慢性哮喘或为了排除其他可能引起喘息的疾病，则选择患者进行支气管镜检查。他们的平均 (SD) 年龄和中位年龄分别为 32.2 岁 (38.3 岁) 和 17.5 个月。细菌培养阳性发生率为 12.1%（33/273 例患者）。细菌菌群包括流感嗜血杆菌（39.5%，15/38）、卡他菌（23.7%，9/38）、奈瑟菌属（7.9%，3/38）、肺炎支原体（7.9%，3/38）、非铜绿假单胞菌（5.3%，2/38）和铜绿假单胞菌（2.6%， 1/38)。然而，目前这一发现的临床意义仍不清楚。
The aims of this retrospective study were to (i) determine the risk of contamination of lower respiratory tract samples obtained during fiberoscopy in children; (ii) determine the incidence and profile of the bacterial flora of the lower respiratory tract in a selected group of asthmatic children at high risk For bacterial infection; and (iii) identify risk markers for such findings. In 29 asthmatic children, comparison of bacterial cultures of specimens obtained from the upper and lower respiratory tracts showed that contamination was a possibility in only 3.4% (1/29) of cases. The results from bacterial samples obtained via flexible bronchoscopy in a further 273 consecutively investigated physician-diagnosed asthmatic children were analysed. Patients were selected for bronchoscopy if they had severe chronic asthma or in order to exclude other diseases able to provoke wheezing. Their mean (SD) and median ages were 32.2 (38.3) and 17.5 mo, respectively. The incidence of positive bacterial cultures was 12.1% (33/273 patients). Bacterial flora included H. influenzae (39.5%, 15/38), B. catarrhalis (23.7%, 9/38), Neisseria species (7.9%, 3/38), M. pneumoniae (7.9%, 3/38, P. non-aeruginosa (5.3%, 2/38) and P. aeruginosa (2.6%, 1/38). No clinical or radiological markers were significantly associated with lower respiratory tract bacterial infection. Large quantities of bacteria were present in the lower respiratory tracts of a substantial number of children (1/8) in this selected group of asthmatics. For the moment, however, the clinical implications of this finding remain unclear.