COVID-19 in Parkinson's Disease Patients Living in Lombardy, Italy
COVID-19 in Parkinson's Disease Patients Living in Lombardy, Italy
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DOI：
10.1002/mds.28176
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发表时间：
2020-06-26
影响因子：
8.6
通讯作者：
Pezzoli, Gianni
中科院分区：
文献类型：
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作者：
Fasano, Alfonso;Cereda, Emanuele;Pezzoli, Gianni
目前尚不清楚PD患者是否有更大的COVID-19风险，他们的风险因素是什么，以及他们的临床表现是否与普通人群不同。目的本研究旨在解决所有这些问题。方法在一项病例对照调查中，我们采访了意大利伦巴第一个三级中心的1,486名PD患者和1,207名家庭成员（对照）。结果105例（7.1%）和92例对照（7.6%）被确定为COVID-19病例。与未受影响的患者相比，COVID-19患者更年轻，更容易患慢性阻塞性肺病，更容易肥胖，并且未补充维生素D。6名患者（5. 7%）和7名家庭成员（7. 6%）死于COVID-19。患者报告呼吸短促和需要住院的可能性较小。结论在一个非晚期PD患者的庞大队列中，COVID-19的风险和死亡率与一般人群没有差异，但症状似乎更轻。补充维生素D可能的保护作用值得进一步研究。(c)2020国际帕金森和运动障碍协会
Background It is unknown whether patients with PD are at greater risk of COVID-19, what their risk factors are, and whether their clinical manifestations differ from the general population. Objectives The study aimed to address all these issues. Methods In a case-controlled survey, we interviewed 1,486 PD patients attending a single tertiary center in Lombardy, Italy and 1,207 family members (controls). Results One hundred five (7.1%) and 92 controls (7.6%) were identified as COVID-19 cases. COVID-19 patients were younger, more likely to suffer from chronic obstructive pulmonary disease, to be obese, and vitamin D nonsupplemented than unaffected patients. Six patients (5.7%) and 7 family members (7.6%) died from COVID-19. Patients were less likely to report shortness of breath and require hospitalization. Conclusions In an unselected large cohort of nonadvanced PD patients, COVID-19 risk and mortality did not differ from the general population, but symptoms appeared to be milder. The possible protective role of vitamin D supplementation warrants future studies. (c) 2020 International Parkinson and Movement Disorder Society