Zip2, a meiosis-specific protein required for the initiation of chromosome synapsis
Zip2, a meiosis-specific protein required for the initiation of chromosome synapsis
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DOI：
10.1016/s0092-8674(00)81164-2
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发表时间：
1998-05-01
期刊：
影响因子：
64.5
通讯作者：
Roeder, GS
中科院分区：
文献类型：
--
作者：
Chua, PR;Roeder, GS
我们描述了酿酒酵母Zip2基因的鉴定和特性，该基因编码一种新的减数分裂特异蛋白，对联会复合体的形成至关重要。在Zip2突变体中，染色体是同源配对的，但没有突触。Zip2蛋白定位于减数分裂染色体上的离散区域；这些区域对应于被认为是突触起始的成对同源基因之间的汇聚点。Zip2p的定位需要减数分裂重组的启动。在一个双链断裂修复缺陷的突变中，Zip2p与参与双链断裂形成和处理的蛋白质共存。我们认为，Zip2p促进了染色体突触的启动，并且Zip2p定位于同源重组位点确保了同源染色体之间的突触。
We describe the identification and characterization of the Saccharomyces cerevisiae ZIP2 gene, which encodes a novel meiosis-specific protein essential for synaptonemal complex formation. In the zip2 mutant, chromosomes are homologously paired but not synapsed. The Zip2 protein localizes to discrete foci on meiotic chromosomes; these foci correspond to sites of convergence between paired homologs that are believed to be sites of synapsis initiation. Localization of Zip2p requires the initiation of meiotic recombination. In a mutant defective in double-strand break repair, Zip2p colocalizes with proteins involved in double-strand break formation and processing. We propose that Zip2p promotes the initiation of chromosome synapsis and that localization of Zip2p to sites of interhomolog recombination ensures synapsis between homologous chromosomes.