Pathohistology of undecalcified primary teeth in vitamin D-resistant rickets - Review and report of two cases
Pathohistology of undecalcified primary teeth in vitamin D-resistant rickets - Review and report of two cases
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DOI：
10.1016/s1079-2104(96)80260-5
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发表时间：
1996-08-01
影响因子：
--
通讯作者：
Geurtsen, W
中科院分区：
文献类型：
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作者：
Hillmann, G;Geurtsen, W
维生素D抵抗性佝偻病的基本牙齿缺陷似乎表现在牙本质中。牙釉质通常报告为正常。组织学检查显示微生物通过釉质层的钙化结构渗透，没有可见的龋齿。微生物通过牙本质-釉质交界处侵入牙本质，以钙球和大量球间牙本质为特征。此外，在牙本质小管中可以检测到微生物，牙本质小管在去除釉质时暴露于口腔中。然而，大面积的三级牙本质延伸之间的小管和牙髓。这些光学显微镜结果表明，临床表现，如牙髓坏死和根尖周病变（无龋损）可能是由微生物通过釉质层的微裂隙渗透以及受影响牙齿的病理改变的釉质显微结构引起的。
The basic dental defects in vitamin D-resistant rickets seem to be manifested in dentin. Enamel is usually reported to be normal. This histologic examination showed the penetration of microorganisms through the calcified structures of the enamel layer without visible caries. The microorganisms passed through the dentinoenamel junction and invaded dentin, which was characterized by calcospherites and large amounts of interglobular dentin. Furthermore, microorganisms could be detected in dentinal tubules, which were exposed to the oral cavity when enamel was removed. However, large areas of tertiary dentin extended between such tubules and the pulp. These light microscopic results suggest that clinical manifestations, such as, pulp recrosis and periapical lesions (without carious defects) may be caused by the penetration of microorganisms through microclefts of the enamel layer as well as pathologically altered enamel microstructures of affected teeth.