FGF21 contributes to neuroendocrine control of female reproduction.
FGF21 contributes to neuroendocrine control of female reproduction.
复制标题
作者：
在营养匮乏期间阻止繁殖是一个保守的适应性过程，对于物种的生存至关重要。在哺乳动物中，饥饿期间抑制怀孕的机制很复杂且尚未完全了解。在这里，我们发现雌性小鼠暴露于 FGF21（一种禁食诱导的肝因子）可模拟饥饿继发的不孕症。从机制上讲，FGF21 作用于下丘脑的视交叉上核 (SCN)，抑制加压素-Kisspeptin 信号级联，从而抑制发情前期黄体生成素的激增。 SCN 中缺乏 FGF21 辅助受体 β-Klotho 的小鼠难以抵抗 FGF21 对女性生育能力的抑制作用。因此，FGF21 定义了一个重要的肝脏-神经内分泌轴，可调节女性生殖以应对营养挑战。
Preventing reproduction during nutritional deprivation is an adaptive process that is conserved and essential for the survival of species. In mammals, the mechanisms that inhibit pregnancy during starvation are complex and incompletely understood. Here we show that exposure of female mice to FGF21, a fasting-induced hepatokine, mimics infertility secondary to starvation. Mechanistically, FGF21 acts on the suprachiasmatic nucleus (SCN) in the hypothalamus to suppress the vasopressin-kisspeptin signaling cascade, thereby inhibiting the proestrus surge in luteinizing hormone. Mice lacking the FGF21 co-receptor, β-Klotho, in the SCN are refractory to the inhibitory effect of FGF21 on female fertility. Thus, FGF21 defines an important liver-neuroendocrine axis that modulates female reproduction in response to nutritional challenge.
登录
查看更多内容
影响因子：
29
作者：
Hondares E;Rosell M;Gonzalez FJ;Giralt M;Iglesias R;Villarroya F
通讯作者：
Villarroya F
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
82.9
作者：
Altarejos, Judith Y.;Goebel, Naomi;Conkright, Michael D.;Inotiel, Hiroshi;Xie, Jianxin;Arias, Carlos M.;Sawchenko, Paul E.;Montminy, Marc
通讯作者：
Montminy, Marc
影响因子：
4.8
作者：
Roa, J.;Garcia-Galiano, D.;Tena-Sempere, M.
通讯作者：
Tena-Sempere, M.
影响因子：
29
作者：
Della Torre, Sara;Rando, Gianpaolo;Maggi, Adriana
通讯作者：
Maggi, Adriana