Tolerance to imidocarb induced experimentally in tick-transmitted Babesia argentina.
Tolerance to imidocarb induced experimentally in tick-transmitted Babesia argentina.
复制标题
在蜱传播的阿根廷巴贝虫中实验诱导对咪唑威的耐受性。
DOI：
10.1111/j.1751-0813.1977.tb00163.x
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发表时间：
1977
影响因子：
1.1
通讯作者：
N. Stewart
中科院分区：
文献类型：
--
作者：
R. J. Dalgliesh;N. Stewart
在一系列4组未切除脾脏的小牛中，通过传播来自感染蜱虫的寄生虫，使阿根廷巴氏随着暴露于咪唑威的次数增加，寄生虫更容易感染治疗的小牛，表明对药物的耐受性增加。对以前未接触过咪虫威的寄生虫和接触过4次的寄生虫进行比较的试验表明，3毫克/千克咪虫威的剂量完全治愈了未接触但未接触的寄生虫的亚临床感染; 1毫克/千克的剂量控制了未接触或接触的寄生虫的急性感染;寄生虫的毒力显然不受接触的影响。
Babesia argentina was repeatedly exposed to imidocarb by transmitting parasites from infected ticks in a series of 4 groups of nonsplenectomised calves that had been treated prophylactically at 2 mg/kg. As the number of exposures to imidocarb increased, the parasites more readily infected the treated calves, indicating increased tolerance to the drug. Tests comparing parasites not previously exposed to imidocarb with those exposed 4 times showed that a dose of 3 mg/kg imidocarb completely cured subclinical infections with non-exposed, but not exposed, parasites; a dose of 1 mg/kg controlled acute infections with either nonexposed or exposed parasites; and the virulence of the parasite was apparently unaffected by the exposures.