Studies on the effect of adrenal on the bioassay of androgen.
Studies on the effect of adrenal on the bioassay of androgen.
复制标题
肾上腺对雄激素生物测定影响的研究。
DOI：
10.1507/endocrj1954.7.61
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发表时间：
1960
期刊：
影响因子：
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通讯作者：
J. Serizawa
中科院分区：
文献类型：
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作者：
J. Serizawa
雄激素的生物测定依赖于去势大鼠精囊和前列腺重量的增加。 Eisenberg和Gordan(1950)采用提肛法测量蛋白质合成代谢效应。这些方法均利用雄激素对因去势而萎缩的各个靶器官的直接作用。一般来说，最理想的生物测定方法是在最敏感的生理条件下进行实验。肾上腺分泌雄激素和雌激素，以及对新陈代谢有重要影响的皮质激素。因此，我们认为，同时去势和去除肾上腺会比单独去势更加增加敏感性，如果这是真的，那么用未成熟大鼠得到的结果将与成年大鼠有所不同。因此，在成年和未成熟大鼠中，去势或去势肾上腺切除术中检查对雄激素的反应，以检查肾上腺对雄激素生物测定的影响。各种器官对雄激素的敏感性并获得了一些新的观察结果。
Bioassay of androgen relies on the increase in weight of seminal vesicle and prostate gland in a castrated rat. Eisenberg and Gordan(1950)used the levator ani method for the measurement of protein anabolic effect. These methods all utilize the direct action of androgen on each target organ atrophied by castration. The most ideal method for bioassay in general is to carry out experiments under the most sensitive physiological condition. Adrenal excretes androgen and estrogen, together with corticoids which have important bearing on the metabolism. Consequently, it was considered that the sensitivity would be more increased by castration and removal of the adrenal at the same time than only by castration and,if this were true,results somewhat different from adult rats would be obtained with immature rats.Reaction to androgen was therefore examined in adult and immature rats,castrated or castrated-adrenalectomized,in order to examine the effect of adrenal on the bioassay of androgen.Further,examinations were also made on the sensitivity of various organs to androgen and some new observations were gained.