Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease.
Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease.
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DOI：
10.3389/fgene.2015.00168
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发表时间：
2015
影响因子：
3.7
通讯作者：
Dalay N
中科院分区：
文献类型：
--
作者：
Işın M;Uysaler E;Özgür E;Köseoğlu H;Şanlı Ö;Yücel ÖB;Gezer U;Dalay N
外泌体是包含包括lncrna在内的多种生物分子的膜性囊泡，参与细胞通讯，由包括癌细胞在内的许多细胞分泌。我们研究了30例前列腺癌（PCa）患者和49例良性前列腺增生患者尿液样本中外泌体GAS5和lincRNA-p21 lncRNA的水平。实时荧光定量PCR检测lncRNA分子。我们观察到前列腺癌和前列腺增生患者外泌体lincRNA-p21水平有显著差异，而GAS5水平没有差异。我们的数据表明，外泌体lincRNA-p21水平的鉴别潜力可能有助于提高前列腺癌患者恶性状态的诊断预测。
Exosomes are membranous vesicles containing various biomolecules including lncRNAs which are involved in cellular communication and are secreted from many cells including cancer cells. In our study, investigated the exosomal GAS5 and lincRNA-p21 lncRNA levels in urine samples from 30 patients with prostate cancer (PCa) and 49 patients with benign prostatic hyperplasia. Quantification of lncRNA molecules was performed by real-time PCR. We observed a significant difference in the exosomal lincRNA-p21 levels between PCa and BPH patients whereas the GAS5 levels did not reveal a difference. Our data suggest that the discriminative potential of exosomal lincRNA-p21 levels may help to improve the diagnostic prediction of the malignant state for patients with PCa.
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影响因子：
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