Animal genomics and infectious disease resistance in poultry.
Animal genomics and infectious disease resistance in poultry.
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DOI：
10.20506/rst.35.1.2421
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发表时间：
2016-04
期刊：
影响因子：
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通讯作者：
Jacqueline Smith;A. Gheyas;D. Burt
中科院分区：
文献类型：
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作者：
Jacqueline Smith;A. Gheyas;D. Burt
禽类病原体对社会造成了重大损失，既给家禽业造成了巨大的经济损失，也给人类健康带来了影响。数以百万计的禽类的健康和福利持续受到许多传染病的威胁，其中一些疾病的毒性正在增加，因此变得更难控制，如马立克氏病病毒和禽流感病毒。在动物基因组学的当前时代，无论是技术还是资源都有了巨大的发展，这意味着研究人员从未像现在这样能够更好地研究疾病抗性的遗传学，并确定使鸟类对感染易感或抗药性的潜在基因/突变。禽类基因组学已经到了可以在禽类和其他禽类中研究和了解传染病的生物学机制的地步。有关赋予抗病能力的基因的知识可用于选择性育种计划或开发有助于控制这些病原体的影响的疫苗，这些病原体对鸟类和人类都有如此重大的影响。
Avian pathogens are responsible for major costs to society, both in terms of huge economic losses to the poultry industry and their implications for human health. The health and welfare of millions of birds is under continued threat from many infectious diseases, some of which are increasing in virulence and thus becoming harder to control, such as Marek's disease virus and avian influenza viruses. The current era in animal genomics has seen huge developments in both technologies and resources, which means that researchers have never been in a better position to investigate the genetics of disease resistance and determine the underlying genes/mutations which make birds susceptible or resistant to infection. Avian genomics has reached a point where the biological mechanisms of infectious diseases can be investigated and understood in poultry and other avian species. Knowledge of genes conferring disease resistance can be used in selective breeding programmes or to develop vaccines which help to control the effects of these pathogens, which have such a major impact on birds and humans alike.