Caspase-2: vestigial remnant or master regulator?
Caspase-2: vestigial remnant or master regulator?
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DOI：
10.1126/scisignal.138pe42
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发表时间：
2008-09-23
影响因子：
7.3
通讯作者：
Ribe, Elena M.
中科院分区：
文献类型：
--
作者：
Troy, Carol M.;Ribe, Elena M.
Caspase-2, the second mammalian caspase to be identified and the most evolutionarily conserved caspase, has eluded classification. The lack of a profound phenotype in the caspase-2–deficient mouse resulted in decreased interest in caspase-2 for many years. However, advances in the field, including the identification of a potential activation complex and the development of methods to detect active caspase-2, now illuminate our understanding of the function of this caspase. These studies suggest that caspase-2 induces death through two pathways. First, caspase-2 induces cell death independently of the mitochondrial pathway, in a manner similar to that of ced-3, a caspase in Caenorhabditis elegans. Second, caspase-2 also induces cell death upstream of the mitochondrial pathway. The choice of pathway may depend on the type of death stimulus. The placing of caspase-2 upstream and independent of mitochondrial dysfunction provides a potentially new therapeutic target for aberrant cell death.
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