MUCOID PSEUDOMONAS-AERUGINOSA IS A MARKER OF POOR SURVIVAL IN CYSTIC-FIBROSIS
MUCOID PSEUDOMONAS-AERUGINOSA IS A MARKER OF POOR SURVIVAL IN CYSTIC-FIBROSIS
复制标题
DOI：
10.1002/ppul.1950120306
复制
发表时间：
1992-03-01
影响因子：
3.1
通讯作者：
PETROVIC, L
中科院分区：
文献类型：
--
作者：
HENRY, RL;MELLIS, CM;PETROVIC, L
本研究的目的是评估囊性纤维化 (CF) 患者痰液中铜绿假单胞菌（muP 和非 muP）的粘液和非粘液分离株的预后意义。 研究招募了 81 名每天咳痰的 CF 儿童，并对其进行了超过 12 个月的随访，并经常进行痰培养。 观察期结束时，他们被分为三个年龄匹配组之一。 在 50 mPs 内被隔离一次或多次； 19 株培养出非 muP，但未培养出 muP，12 株未培养出铜绿假单胞菌分离株。 这 81 名儿童和青少年又被跟踪了 8 年或直到他们死亡。 21 名 muPs 患者死亡（42%），相比之下，2 名非 muPs 患者死亡（11%），1 名无 Ps 患者死亡（8%）（P < 0.01）。 逐步回归表明，1 秒用力呼气量 (FEV1) 具有主要预测作用，但年龄、Shwachman 评分和 muP 也具有预测作用。 铜绿假单胞菌粘液形式的鉴定是不利的预后因素，但非粘液菌株的分离似乎并不比其他常见呼吸道病原体的分离更重要。
The aim of this study was to assess the prognostic significance of mucoid and non-mucoid isolates of Pseudomonas aeruginosa (muPs and non-muPs) from the sputa of patients with cystic fibrosis (CF). Eighty-one children with CF who coughed up sputum daily were recruited and followed over 12 months with frequent sputum cultures. At the end of this observation period they were classified to one of three age-matched groups. In 50 mPs was isolated on one or more occasions; 19 grew non-muPs but not muPs, and 12 grew no isolates of Ps aeruginosa. These 81 children and adolescents were followed for a further 8 years or until they died. Twenty-one (42%) of the muPs patients died compared with two (11%) of the non-muPs and one (8%) of the no Ps patients (P < 0.01). Stepwise regression indicated that forced expiratory volume in 1 second (FEV1) had the main predictive effect but that age, Shwachman score and muPs also had a predictive effect. Identification of mucoid forms of Ps aeruginosa is an unfavorable prognostic factor but the isolation of non-mucoid strains does not appear to be any more important than the isolation of other common respiratory pathogens.