Antiphospholipid syndrome: pathogenic mechanisms
Antiphospholipid syndrome: pathogenic mechanisms
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DOI：
10.1016/s1568-9972(02)00144-1
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发表时间：
2003-03-01
影响因子：
13.6
通讯作者：
Shoenfeld, Y
中科院分区：
文献类型：
--
作者：
Espinosa, G;Cervera, R;Shoenfeld, Y
尽管抗磷脂抗体（aPL）与血栓形成之间存在密切关联，但 aPL 在血栓形成中的致病作用尚未完全阐明。所提出的病理生理机制可分为两种类型。首先，aPL 可能通过破坏细胞膜上发生的正常促凝血和抗凝血反应的动力学来在体内发挥作用。其次，aPL 可能会刺激某些细胞，从而改变各种分子的表达和分泌。在本文中，我们回顾了 aPL 可能发生血栓事件的机制。 (C)) 2002 Elsevier Science B.V. 保留所有权利。
Despite the strong association between antiphospholipid antibodies (aPL) and thrombosis, the pathogenic role of aPL in the development of thrombosis has not been fully elucidated. Proposed pathophysiological mechanisms may be categorized into two types. First, aPL may act in vivo by disrupting the kinetics of the normal procoagulant and anticoagulant reactions occurring on cell membranes. Second, aPL may stimulate certain cells thereby altering the expression and secretion of various molecules. In this article, we review the mechanisms by which aPL may develop thrombotic events. (C)) 2002 Elsevier Science B.V. All rights reserved.