The Rules of Attraction in Central Nervous System Myelination.

The Rules of Attraction in Central Nervous System Myelination.
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DOI:
10.3389/fncel.2018.00367
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发表时间:
2018
影响因子:
5.3
通讯作者:
Almeida RG
Almeida RG
中科院分区:
医学2区
文献类型:
--
作者:
Almeida RG

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髓鞘包裹轴突对脊椎动物中枢神经系统的发育和功能至关重要,对动作电位的传导起着重要的调节作用。少突胶质细胞是中枢神经系统的髓鞘生成胶质细胞,在体外具有将髓磷脂包裹在任何允许结构周围的内在倾向,但在体内,髓磷脂仅以显着的特异性靶向某些轴突。尽管髓鞘形成的重要性,少突胶质细胞导航复杂的环境,包括许多类型的细胞和它们的细胞投射,并选择只有某些轴突髓鞘形成的机制仍然不完全理解。在这篇小综述中,我强调了最近的研究,阐明了中枢神经系统髓鞘靶向的分子和细胞规则。
The wrapping of myelin around axons is crucial for the development and function of the central nervous system (CNS) of vertebrates, greatly regulating the conduction of action potentials. Oligodendrocytes, the myelinating glia of the CNS, have an intrinsic tendency to wrap myelin around any permissive structure in vitro, but in vivo, myelin is targeted with remarkable specificity only to certain axons. Despite the importance of myelination, the mechanisms by which oligodendrocytes navigate a complex milieu that includes many types of cells and their cellular projections and select only certain axons for myelination remains incompletely understood. In this Mini-review, I highlight recent studies that shed light on the molecular and cellular rules governing CNS myelin targeting.
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