Diagnosis and Staging of Medication-Related Osteonecrosis of the Jaw
Diagnosis and Staging of Medication-Related Osteonecrosis of the Jaw
复制标题
DOI：
10.1016/j.coms.2015.06.008
复制
发表时间：
2015-11-01
影响因子：
1.5
通讯作者：
Ruggiero, Salvatore L.
中科院分区：
文献类型：
--
作者：
Ruggiero, Salvatore L.
颌骨骨坏死与双膦酸盐治疗之间的关系最初是在10多年前建立的。从那时起，我们对这种疾病过程的理解随着临床、基础科学和动物研究计划的直接结果而不断发展。药物相关性颌骨骨坏死（MRONJ）是一个众所周知的实体，现在已知与各种抗吸收治疗和最近的抗血管生成药物有关。本文综述了最近修订的MRONJ诊断标准，重点介绍了该疾病的临床、组织病理学和影像学特征。
The relationship between osteonecrosis of the jaw and bisphosphonate therapy was initially established more than 10 years ago. Since that time, our understanding of this disease process has evolved as the direct result of clinical, basic science, and animal research initiatives. Medication-related osteonecrosis of the jaw (MRONJ) is a well-known entity now known to be associated with various antiresorptive therapies and recently with antiangiogenic medications. This article reviews the recently modified diagnostic criteria for MRONJ with a focus on the clinical, histopathologic, and imaging characteristics of this disease process.