Parental age at delivery, birth order, birth weight and gestational age are associated with the risk of childhood Type 1 diabetes: a UK regional retrospective cohort study
Parental age at delivery, birth order, birth weight and gestational age are associated with the risk of childhood Type 1 diabetes: a UK regional retrospective cohort study
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DOI：
10.1111/j.1464-5491.2005.01369.x
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发表时间：
2005-02-01
影响因子：
3.5
通讯作者：
Patterson, CC
中科院分区：
文献类型：
--
作者：
Cardwell, CR;Carson, DJ;Patterson, CC
目的探讨围产期的危险因素为儿童1型糖尿病在英国人口cohol.Methods围产期数据已被常规记录在北方爱尔兰的所有出生在1971-86年期间（n = 447 663）。从1971 ~ 2001年出生于1971- 86年的1079例1型糖尿病患儿中筛选出991例15岁时的糖尿病患病情况。结果母亲年龄、父亲年龄、出生体重、胎龄体重和胎龄较低与1型糖尿病患病风险增加有关。校正母亲年龄后，1型糖尿病与父亲年龄之间的相关性仍然显著[相对风险（RR）= 1.52（1.10，2.09），比较父亲年龄35岁或以上与小于25岁]，但反之亦然[RR = 1.11（0.80，1.54），比较母亲年龄35岁或以上与小于25岁]。出生顺序增加与1型糖尿病风险显著降低相关[调整后的RR = 0.75（0.62，0.90），将出生顺序3或3以上与头胎进行比较]，但这只有在对母亲年龄进行调整后才变得明显。此外，这种关联与出生顺序是显着的糖尿病诊断的年龄在5 years.Conclusions，我们的分析表明，第一次在英国的区域队列设置，母亲的年龄和父亲的年龄在交付，出生顺序，出生体重和胎龄显着相关的1型糖尿病的风险。
Aims To investigate perinatal risk factors for childhood Type 1 diabetes in a UK population cohort.Methods Perinatal data have been routinely recorded in Northern Ireland for all births in the period 1971-86 (n = 447 663). Diabetes status at the age of 15 years was ascertained in this cohort by identifying 991 children from 1079 registered with Type 1 diabetes diagnosed from 1971 to 2001 and date of birth in the period 1971-86.Results Increased Type 1 diabetes risk was associated with higher maternal age, paternal age, birth weight and birth weight for gestational and lower gestational age. After adjustment for maternal age, the association between Type 1 diabetes and paternal age remained significant [relative risk (RR) = 1.52 (1.10, 2.09) comparing father's age 35 years or more to less than 25 years] but not vice versa [RR = 1.11 (0.80, 1.54) comparing mother's age 35 years or more to less than 25 years]. Increased birth order was associated with a significant decrease in the risk of Type 1 diabetes [adjusted RR = 0.75 (0.62, 0.90) comparing birth order three or more with firstborn], but this only became apparent when adjustment was made for maternal age. Furthermore this association with birth order was significant only for diabetes diagnosed under the age of 5 years.Conclusions Our analysis demonstrates, for the first time in a UK regional cohort setting, that maternal age and paternal age at delivery, birth order, birth weight and gestational age are significantly associated with Type 1 diabetes risk.