Comparison of gastric volumes in response to isocaloric liquid and mixed meals in humans
Comparison of gastric volumes in response to isocaloric liquid and mixed meals in humans
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DOI：
10.1111/j.1365-2982.2004.00533.x
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发表时间：
2004-10-01
影响因子：
3.5
通讯作者：
Burton, D
中科院分区：
文献类型：
--
作者：
De Schepper, H;Camilleri, M;Burton, D
目的：比较等热量液体或混合(固体-液体)餐对胃体积的反应，并证明静脉注射后使用单光子发射计算机断层成像(SPECT)测量胃体积的个体内和个体间的重复性。方法：8名健康志愿者进行两次研究，间隔至少9个月。在317千卡的液体营养餐后测量胃体积。在第二次液体餐研究的两周内，参与者进行了第三次研究，摄入了一份等卡路里的混合餐。结果：两种液体餐的空腹和餐后胃体积无显著差异，个体间和个体内变异系数分别为13%和13.8%。与流质餐相比，混合餐的绝对餐后容量和空腹时胃容量的变化均较小(P=0.0001)。结论：SPECT对营养液体餐后胃容量的测量是重复性的。与等热量混合餐相比，液态餐后的体积响应幅度更大。
Aims: To compare gastric volume responses to ingestion of isocaloric liquid or mixed (solid-liquid) meals and document the intra- and interindividual reproducibility of gastric volume measurement using single photon emission computed tomography (SPECT) imaging after i.v. Tc-99m-pertechnetate.Methods: Eight healthy volunteers performed two studies at least 9 months apart. Gastric volumes were measured after a 317 kcal liquid nutrient meal. Within 2 weeks of the second liquid meal study, participants performed a third study, ingesting an isocaloric mixed meal. The order of the mixed and second liquid meals was randomized, Bland-Altman plot displayed data on repeated studies with liquid meal and paired t-test compared gastric volumes after mixed or liquid isocaloric meals.Results: Fasting and postprandial gastric volumes associated with the two liquid meals were not significantly different; inter- and intra-individual coefficients of variation were 13 and 13.8%. In response to the mixed meal, there was a lower absolute postprandial volume and lower change in gastric volume over fasting volume compared with the response to the liquid meal (P = 0.0001).Conclusion: The SPECT measurement of gastric volumes in response to a nutrient liquid meal is reproducible. The magnitude of the volume response is greater after the liquid meal compared with the isocaloric mixed meal.