Probing the micro- and nanoscopic properties of dental materials using infrared spectroscopy: A proof-of-principle study
Probing the micro- and nanoscopic properties of dental materials using infrared spectroscopy: A proof-of-principle study
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DOI：
10.1016/j.actbio.2023.07.017
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发表时间：
2023-08-18
影响因子：
9.7
通讯作者：
Tittl，Andreas
中科院分区：
文献类型：
--
作者：
Beddoe，Max;Goelz，Thorsten;Tittl，Andreas
在人的一生中保持口腔健康是高质量生活的关键因素。维持口腔健康需要具有耐用性、无毒性和易用性等多种属性的高端牙科材料。不同要求的结合导致了复合材料和粘合剂等材料成分的小型化和复杂性的增加，这使得材料混合物的精确表征变得具有挑战性。在这里，我们展示了从微米到纳米尺度的现代红外光谱和成像如何提供对牙齿填充的不同材料部分的化学成分的洞察。我们展示了如何使用记录的红外图像来快速且无损地测定所研究的胶粘剂的孔隙率。此外，这项纳米级研究可以精确评估玻璃团簇的结构和在其特有的有机改性陶瓷(ORMOCER)基质中的分布，并评估复合材料和粘结剂材料之间的界面。在这项研究中，我们使用傅立叶变换红外显微镜(FTIR)和量子级联激光红外显微镜(QCL-IR)进行微观分析，使用散射型扫描近场光学显微镜(S-SNOM)进行纳米尺度分析。文章最后深入讨论了不同成像方法的优缺点，以使读者清楚地了解显微镜最适合解决哪些科学问题。意义陈述现代树脂基牙修复复合材料是复杂的多层复合材料。为了改善这些高端材料，重要的是要研究不同部分的分子组成和形态。表征这些材料的一种紧急方法是红外光谱成像，它结合了红外光谱的力量和光学显微镜已知的成像方法。在这项工作中，比较了三种最先进的方法来研究牙齿填充，包括微尺度的FTIR和量子级联激光红外成像显微镜和纳米尺度的散射型扫描近场光学显微镜。
The preservation of oral health over a person's lifespan is a key factor for a high quality of life. Sustaining oral health requires high-end dental materials with a plethora of attributes such as durability, non-toxicity and ease of application. The combination of different requirements leads to increasing miniaturization and complexity of the material components such as the composite and adhesives, which makes the precise characterization of the material blend challenging. Here, we demonstrate how modern IR spectroscopy and imaging from the micro- to the nanoscale can provide insights on the chemical composition of the different material sections of a dental filling. We show how the recorded IR-images can be used for a fast and non-destructive porosity determination of the studied adhesive. Furthermore, the nanoscale study allows precise assessment of glass cluster structures and distribution within their characteristic organically modified ceramic (ORMOCER) matrix and an assessment of the interface between the composite and adhesive material. For the study we used a Fourier-Transform-IR (FTIR) microscope and a quantum cascade laser-based IR-microscope (QCL-IR) for the microscale analysis and a scattering-type scanning near-field optical microscopy (s-SNOM) for the nanoscale analysis. The paper ends with an in-depth discussion of the strengths and weaknesses of the different imaging methods to give the reader a clear picture for which scientific question the microscopes are best suited for.Statement of significanceModern resin-based composites for dental restoration are complex multi-compound materials. In order to improve these high-end materials, it is important to investigate the molecular composition and morphology of the different parts. An emergent method to characterize these materials is infrared spectroscopic imaging, which combines the strength of infrared spectroscopy and an imaging approach known from optical microscopy. In this work, three state of the art methods are compared for investigating a dental filling including FTIR- and quantum cascade laser IR-imaging microscopy for the microscale and scattering-type scanning near-field optical microscopy for the nanoscale.