Regularly alternating L,D‐peptides. II. The double‐stranded right‐handed antiparallel β‐helix in the structure of t‐Boc‐(L‐Phe‐D‐Phe)4‐OMe
Regularly alternating L,D‐peptides. II. The double‐stranded right‐handed antiparallel β‐helix in the structure of t‐Boc‐(L‐Phe‐D‐Phe)4‐OMe
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t-Boc-(L-Phe-D-Phe)4-OMe 结构中的双链右手反平行 β 螺旋定期交替。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
G. P. Lorenzi
中科院分区：
文献类型：
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作者：
B. di Blasio;E. Benedetti;V. Pavone;C. Pedone;Cristoph Gerber;G. P. Lorenzi
用x射线衍射分析确定了Boc‐（L‐Phe‐D‐Phe）4‐OMe的晶体结构。肽在三斜体系中结晶，空间群P1为a = 15.290 Å， b = 15.163 Å， c = 19.789 Å， α = 102.49°，β = 96.59°，γ = 74.22°，Z = 2。通过对已知相集进行切线公式细化，结合分子置换技术和展开技术求解了该结构。经过几次傅里叶计算和最小二乘改进，确定了两个独立的八肽链的194个原子和一些共结晶溶剂分子（氯仿、水和甲醇）的位置。对于3077个“观测到的”反射，各向同性的细化收敛到R = 0.13。
The crystal structure of Boc‐(L‐Phe‐D‐Phe)4‐OMe has been determined by x‐ray diffraction analysis. The peptide crystallizes in the triclinic system, space group P1 with a = 15.290 Å, b = 15.163 Å, c = 19.789 Å, α = 102.49°, β = 96.59°, γ = 74.22°, and Z = 2. The structure has been solved by coupling of the molecular replacement technique and expansion by tangent formula refinement of the set of known phases. Several cycles of Fourier calculations and least‐squares refinement led to the location of 194 atoms of the two independent octapeptide chains and few molecules of cocrystallized solvent (chloroform, water, and methanol). The isotropic refinement converged to R = 0.13 for the 3077 “observed” reflections.
DOI：
10.1111/j.1399-3011.1983.tb02062.x
发表时间：
1983
期刊：
International journal of peptide and protein research
影响因子：
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作者：
Benedetti,E;Morelli,G;Némethy,G;Scheraga,HA
通讯作者：
Scheraga,HA