No Genetic Association between Polymorphisms of Heme Oxygenase 1 and 2 and Alzheimer’s Disease in a Japanese Population
No Genetic Association between Polymorphisms of Heme Oxygenase 1 and 2 and Alzheimer’s Disease in a Japanese Population
复制标题
DOI：
10.1159/000203891
复制
发表时间：
2009-02
影响因子：
2.4
通讯作者：
N. Shibata;T. Ohnuma;H. Baba;H. Arai
中科院分区：
文献类型：
--
作者：
N. Shibata;T. Ohnuma;H. Baba;H. Arai
背景/目的：最近研究表明，血红素加氧酶Hmox1和Hmox2可能在阿尔茨海默病(AD)的发病机制中起作用。方法：采用TaqMan技术对180例AD患者和132例正常对照的Hmox1和Hmox2基因5个单核苷酸多态性(SNPs)进行基因分型，以探讨Hmox1和Hmox2基因与AD的关系。结果：我们的研究未能检测到Hmox1和Hmox2基因的SNPs与AD之间的任何关联。此外，在我们的AD患者中，我们没有观察到所研究的SNPs与载脂蛋白E之间的任何协同关联。结论：这两个基因与阿尔茨海默病的关系有待进一步的遗传学研究。
Background/Aims: Recently, it has been shown that the heme oxygenases HMOX1 and HMOX2 might play a role in the pathogenesis of Alzheimer’s disease (AD). Methods: To investigate whether there is any association between the HMOX1 and HMOX2 genes and AD, five single nucleotide polymorphisms (SNPs) in each gene were genotyped in 180 AD patients and 132 age-matched controls using TaqMan technology. Results: Our study failed to detect any association between the SNPs of the HMOX1 and HMOX2 genes and AD. In addition, we did not observe any synergetic association between the SNPs studied and apolipoprotein E in our AD patients. Conclusion: Further genetic studies are needed to clarify the relationship between the two genes and AD.