The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy
The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy
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DOI：
10.1016/j.fertnstert.2009.12.079
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发表时间：
2010-11-01
影响因子：
6.7
通讯作者：
Steegers-Theunissen, Regine P. M.
中科院分区：
文献类型：
--
作者：
Vujkovic, Marijana;de Vries, Jeanne H.;Steegers-Theunissen, Regine P. M.
目的：研究孕前饮食模式与IVF/卵胞浆内单精子注射（ICSI）结局之间的关系，该结局经同型半胱氨酸途径生物标志物验证。设计：观察性前瞻性研究。设置：荷兰鹿特丹伊拉斯谟大学医学中心三级转诊生育诊所。患者：161对接受IVF/ICSI治疗的夫妇。干预措施：没有干预措施以外的荷兰政府建议的folica.Main结果Measure（S）：饮食模式，血液和卵泡液浓度的叶酸，维生素B12，维生素B6，同型半胱氨酸，受精率，胚胎质量，和pregnancy. Results（S）：在妇女中，两种饮食模式被确定。“健康意识低加工”的饮食模式（变异解释12.1%）的特点是高摄入量的水果，蔬菜，鱼类和全谷物和低摄入量的零食，肉类和蛋黄酱，并与红细胞叶酸呈正相关（β =0.07）。“地中海”饮食模式（变异解释率为9.1%），即植物油、蔬菜、鱼和豆类的高摄入量和零食的低摄入量，与红细胞叶酸（β =0.13）、血液中的维生素B6（β =0.09）和卵泡液（β =0.18）呈正相关。高坚持夫妇的“地中海”饮食增加怀孕的概率，优势比1.4（95%置信区间1.0-1.9）。结论：孕前“地中海”饮食的夫妇接受IVF/ICSI治疗有助于成功实现怀孕。（Fertil Steril（R）2010; 94：2096-101. (C)美国生殖医学会（American Society for Reproductive Medicine）
Objective: To investigate associations between preconception dietary patterns and IVF/intracytoplasmic sperm injection (ICSI) outcomes validated by biomarkers of the homocysteine pathway.Design: Observational prospective study.Setting: A tertiary referral fertility clinic at the Erasmus University Medical Centre, Rotterdam, The Netherlands.Patient(s): One hundred sixty-one couples undergoing IVF/ICSI treatment. Intervention(s): No interventions other than the Dutch governmental recommendation of folic acid.Main Outcome Measure(s): Dietary patterns, blood and follicular fluid concentrations of folate, vitamin B12, vitamin B6, homocysteine, and fertilization rate, embryo quality, and pregnancy.Result(s): In women, two dietary patterns were identified. The "health conscious-low processed" dietary pattern (variation explained 12.1%) was characterized by high intakes of fruits, vegetables, fish, and whole grains and low intakes of snacks, meats, and mayonnaise, and positively correlated with red blood cell folate (beta=0.07). The "Mediterranean" dietary pattern (variation explained 9.1%), that is, high intakes of vegetable oils, vegetables, fish, and legumes and low intakes of snacks, was positively correlated with red blood cell folate (beta=0.13), and vitamin B6 in blood (beta=0.09) and follicular fluid (beta=0.18). High adherence by the couple to the "Mediterranean" diet increased the probability of pregnancy, odds ratio 1.4 (95% confidence interval 1.0-1.9).Conclusion(s): A preconception "Mediterranean" diet by couples undergoing IVF/ICSI treatment contributes to the success of achieving pregnancy. (Fertil Steril (R) 2010; 94: 2096-101. (C) 2010 by American Society for Reproductive Medicine.)