INFLUENZA-A VIRUS-INDUCED POLYMORPHONUCLEAR LEUKOCYTE DYSFUNCTION IN THE PATHOGENESIS OF EXPERIMENTAL PNEUMOCOCCAL OTITIS-MEDIA
INFLUENZA-A VIRUS-INDUCED POLYMORPHONUCLEAR LEUKOCYTE DYSFUNCTION IN THE PATHOGENESIS OF EXPERIMENTAL PNEUMOCOCCAL OTITIS-MEDIA
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DOI：
10.1128/iai.36.1.289-296.1982
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发表时间：
1982-01-01
影响因子：
3.1
通讯作者：
QUIE, PG
中科院分区：
文献类型：
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作者：
ABRAMSON, JS;GIEBINK, GS;QUIE, PG
本实验研究了流感病毒感染引起的多形核白细胞和咽鼓管功能障碍在灰鼠急性化脓性中耳炎发病中的作用。观察鼻内接种A型流感病毒、肺炎链球菌或两者同时接种后白细胞功能、中耳压力和肺炎球菌性中耳炎的发生率。结果表明，接种流感病毒后，中耳负压和多形核白细胞化学发光和趋化活性降低，但单独接种肺炎球菌后则没有。肺炎球菌性中耳炎的最大发病率发生在流感诱导的多形核白细胞功能障碍和中耳负压之前接种肺炎球菌的时候。在接种流感病毒和肺炎球菌之前放置单侧鼓膜造孔管的动物在通气和非通气耳中的肺炎球菌性中耳炎的发生率没有差异，这表明在该动物模型中，多形核白细胞功能障碍比负中耳压力更有助于肺炎球菌性中耳炎的发病机制。
The role of influenza A virus-induced polymorphonuclear leukocyte and eustachian tube dysfunction in the pathogenesis of acute purulent otitis media was studied in chinchillas. Polymorphonuclear leukocyte function, middle ear pressure and the incidence of pneumococcal otitis media were observed after intranasal inoculation with influenza A virus, Streptococcus pneumoniae, or both. Results showed that depressed negative middle ear pressure and polymorphonuclear leukocyte chemiluminescence and chemotactic activity occurred after influenza inoculation, but not after inoculation with pneumococcus alone. The greatest incidence of pneumococcal otitis media occurred when the pneumococcus was inoculated just before the time of influenza-induced polymorphonuclear leukocyte dysfunction and negative middle ear pressure. Animals that had unilateral tympanostomy tubes placed before inoculation of influenza with pneumococcus showed no difference in the occurrence of pneumococcal otitis media in ventilated and nonventilated ears, suggesting that polymorphonuclear leukocyte dysfunction contributes more to the pathogenesis of pneumococcal otitis media than does negative middle ear pressure in this animal model.