Age-related slowing of memory retrieval: Contributions of perceptual speed and cerebral white matter integrity
Age-related slowing of memory retrieval: Contributions of perceptual speed and cerebral white matter integrity
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DOI：
10.1016/j.neurobiolaging.2007.02.008
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发表时间：
2008-07-01
影响因子：
4.2
通讯作者：
Huettel, Scott A.
中科院分区：
文献类型：
--
作者：
Bucur, Barbara;Madden, David J.;Huettel, Scott A.
先前的研究表明，在情景记忆检索的反应时间（RT）测量中，与衰老对感知速度等更基本能力的影响相比，成年年龄的独特影响相对较小。然而，人们对知觉速度的机制知之甚少。我们使用扩散张量成像（DTI）来检验这样的假设：白质完整性（以分数各向异性（EA）为索引）是情景记忆检索中知觉减慢的一种机制。结果表明，胼周额叶区和胼胝体膝部的 FA 下降，但其他区域没有，介导了知觉速度和情景检索 RT 之间的关系。这种关系对于命中和正确拒绝都成立，尽管程度不同。这些发现表明，前额叶区域的白质完整性是感知速度个体差异与情景检索之间关系的一种机制。 (C) 2007 Elsevier Inc. 保留所有权利。
Previous research suggests that, in reaction time (RT) measures of episodic memory retrieval, the unique effects of adult age are relatively small compared to the effects aging shares with more elementary abilities such as perceptual speed. Little is known, however, regarding the mechanisms of perceptual speed. We used diffusion tensor imaging (DTI) to test the hypothesis that white matter integrity, as indexed by fractional anisotropy (EA), serves as one mechanism of perceptual slowing in episodic memory retrieval. Results indicated that declines in FA in the pericallosal frontal region and in the genu of the corpus callosum, but not in other regions, mediated the relationship between perceptual speed and episodic retrieval RT. This relation held, though to a different degree, for both hits and correct rejections. These findings suggest that white matter integrity in prefrontal regions is one mechanism underlying the relation between individual differences in perceptual speed and episodic retrieval. (C) 2007 Elsevier Inc. All rights reserved.