Whole-Body MR Imaging in the German National Cohort:Rationale, Design, and Technical Background
Whole-Body MR Imaging in the German National Cohort:Rationale, Design, and Technical Background
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DOI：
10.1148/radiol.2015142272
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发表时间：
2015-10-01
期刊：
影响因子：
19.7
通讯作者：
Voelzke, Henry
中科院分区：
文献类型：
--
作者：
Bamberg, Fabian;Kauczor, Hans-Ulrich;Voelzke, Henry
目的：为了详细说明的理由，设计，并在德国国家队列，一个大型的多中心人口为基础的study.Materials和方法：所有机构的审查委员会批准了这项研究，并获得知情同意之前，研究招募全身磁共振（MR）成像的未来前景。参与者从18个招募中心中的5个专用成像站点的一般人群的随机样本中招募。磁共振成像设施配备了相同的3.0-T成像仪技术，并使用统一的磁共振协议。特定于成像仪的硬件和软件设置在研究期间保持不变。图像质量的现场和集中测量使得能够监测采集的完整性和每个MR序列的质量。认证的放射科医生阅读所有的MR成像研究存在的偶然发现根据预定义的algorithm.Results：在4年的时间内，每天有6名参与者在每个中心进行检查，总计约30 000名参与者的最终成像队列。每个研究中心的MR成像方案相同，包括一组12个本地系列，涵盖神经、心血管、胸腹和肌肉骨骼成像表型，总计约1小时的成像时间。作为中央成像核心的一部分的专用分析平台结合了基于瘦客户端的集成和模块化数据处理平台，以实现多中心非现场图像阅读以获得偶然发现。科学分析将追求每个项目hypothesis-driven的basis.Conclusion：人口为基础的全身MR成像的一部分，德国国家队列将有助于编译一个全面的图像库，将提供洞察生理变异和亚临床疾病负担，并有可能使识别新的成像生物标志物的风险。(C)RSNA，2015年
Purpose: To detail the rationale, design, and future perspective of implementing whole-body magnetic resonance (MR) imaging in the German National Cohort, a large multicentric population-based study.Materials and Methods: All institutional review boards approved the study, and informed consent is obtained before study enrollment. Participants are enrolled from a random sample of the general population at five dedicated imaging sites among 18 recruitment centers. MR imaging facilities are equipped with identical 3.0-T imager technology and use uniform MR protocols. Imager-specific hardware and software settings remained constant over the study period. On-site and centralized measures of image quality enable monitoring of completeness of the acquisitions and quality of each of the MR sequences. Certified radiologists read all MR imaging studies for presence of incidental findings according to predefined algorithms.Results: Over a 4-year period, six participants per day are examined at each center, totaling a final imaging cohort of approximately 30 000 participants. The MR imaging protocol is identical for each site and comprises a set of 12 native series to cover neurologic, cardiovascular, thoracoabdominal, and musculoskeletal imaging phenotypes totaling approximately 1 hour of imaging time. A dedicated analysis platform as part of a central imaging core incorporates a thin client-based integrative and modular data handling platform to enable multicentric off-site image reading for incidental findings. Scientific analysis will be pursued on a per-project hypothesis-driven basis.Conclusion: Population-based whole-body MR imaging as part of the German National Cohort will serve to compile a comprehensive image repository, will provide insight into physiologic variants and subclinical disease burden, and has the potential to enable identification of novel imaging biomarkers of risk. (C) RSNA, 2015