Long-term sequelae of pneumococcal meningitis in children
Long-term sequelae of pneumococcal meningitis in children
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DOI：
10.1177/000992289603500204
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发表时间：
1996-02-01
影响因子：
1.6
通讯作者：
Manios, S
中科院分区：
文献类型：
--
作者：
Pikis, A;Kavaliotis, J;Manios, S
这项研究的目的是评估肺炎球菌脑膜炎对儿童的长期影响。1967年至1988年，希腊塞萨洛尼基传染病医院共收治90名被诊断为肺炎球菌脑膜炎的儿童。16名患者在医院死亡，直接原因是脑膜炎。其他11人被排除在研究之外(脑膜炎发作前的神经功能障碍，2人；住院后死亡，2人；复发性脑膜炎，7人)，在其余63名幸存者中，我们能够评估47名患者(75%)。评估时间为出院后23年(平均12.3+/-5.8年)。40例患者返回医院进行评估，7例由主治医生进行评估，主治医生通过标准化问卷发送信息，进行以下检查：病史、身体和神经检查、眼科和听力评估、精神测量测试，14例(30%)患者至少有一项神经功能障碍；9例(19%)智力低下，8例(17%)听力损失，7例(15%)癫痫发作障碍，5例(11%)运动缺陷，1例(2%)行为问题和视力障碍，昏迷是发病率增加的最强预测因素。在我们的研究中观察到的长期后遗症的高频率支持了有效疫苗的必要性。
The purpose of this study was to assess the long-term effects of pneumococcal meningitis in children. From 1967 to 1988, a total of 90 children were admitted to the Hospital for Infectious Diseases, Thessaloniki, Greece, with the diagnosis of pneumococcal meningitis. Sixteen patients died in the hospital as a direct result of meningitis. Eleven others were excluded from the study (neurologic deficits prior to onset of meningitis, two; death subsequent to hospitalization, two; recurrent meningitis, seven), Of the remaining 63 survivors, we were able to evaluate 47 patients (75%). Evaluation was performed il to 23 years (mean 12.3 +/- 5.8 years) after discharge. Forty patients returned to hospital for evaluation, and seven were evaluated by their primary physicians, who sent information by a standardized questionnaire, The following examinations were carried out: history, physical and neurologic examination, ophthalmologic and hearing evaluation, and psychometric testing, Fourteen patients (30%) had at least one neurologic handicap; nine (19%) had mental retardation, eight (17%) hearing loss, seven (15%) seizure disorder, five (11%) motor defects, and one each (2%) behavioral problems and visual impairment, The presence of coma was the strongest predictor of increased morbidity. The high frequency of long-term sequelae observed in our study supports the need of an effective vaccine.