Plasticity in glutamatergic NTS neurotransmission.

Plasticity in glutamatergic NTS neurotransmission.
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DOI:
10.1016/j.resp.2008.04.013
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发表时间:
2008-12-10
影响因子:
2.3
通讯作者:
Kline, David D.
Kline, David D.
中科院分区:
医学4区
文献类型:
--
作者:
Kline, David D.

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动物或人类生理状态的变化可导致心血管和呼吸系统的改变,以维持体内平衡。因此,心血管和呼吸系统不是静态的,而是在各种情况下容易适应。控制这些系统的脑干回路也是如此。孤束核(NTS)是压力感受器和化学感受器感觉传入纤维的中枢整合部位。这个中央核团,特别是感觉传入和二级NTS细胞之间的突触,在对各种刺激(包括急性和慢性刺激)的反应中具有显著的可塑性。这篇简短的评论旨在描述NTS中观察到的可塑性以及目前所了解的轨迹和机制。NTS可塑性的功能后果进行了讨论。
Changes in the physiological state of an animal or human can result in alterations in the cardiovascular and respiratory system in order to maintain homeostasis. Accordingly, the cardiovascular and respiratory systems are not static but readily adapt under a variety of circumstances. The same can be said for the brainstem circuits that control these systems. The nucleus tractus solitarius (NTS) is the central integration site of baroreceptor and chemoreceptor sensory afferent fibers. This central nucleus, and in particular the synapse between the sensory afferent and second-order NTS cell, possesses a remarkable degree of plasticity in response to a variety of stimuli, both acute and chronic. This brief review is intended to describe the plasticity observed in the NTS as well as the locus and mechanisms as they are currently understood. The functional consequence of NTS plasticity is also discussed.
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