Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder
Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder
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DOI：
10.1176/appi.ajp.157.7.1120
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发表时间：
2000-07-01
影响因子：
17.7
通讯作者：
Charney, DS
中科院分区：
文献类型：
--
作者：
Bremner, JD;Innis, RB;Charney, DS
目的：应激动物额叶皮质苯二氮卓类受体结合量减少。尚无研究检测创伤后应激障碍(PTSD)患者的中枢苯二氮卓类受体结合。方法：对13例越战相关创伤后应激障碍患者和13例健康对照组的苯二氮卓类受体结合量(分布体积)进行单光子发射计算机断层扫描(SPECT)[I-123]Iomazenil结合成像和血浆放射性配基浓度测定。结果：PTSD患者前额叶皮质(Brodmann‘s Area 9)的分布体积低于对照组。结论：PTSD患者前额叶内侧皮质苯二氮卓类受体结合量偏低与其受体亲和力降低相一致。该区域苯二氮卓类受体功能的改变可能是创伤后应激障碍的许多症状的基础。
Objective: Animals exposed to stress exhibit a decrease in benzodiazepine receptor binding in the frontal cortex. No studies have examined central benzodiazepine receptor binding in patients with posttraumatic stress disorder (PTSD). The purpose of this study was to examine measures of benzodiazepine receptor binding in PTSD.Method: From 13 patients with Vietnam combat-related PTSD and 13 case-matched healthy comparison subjects, a quantitative measure related to benzodiazepine receptor binding (distribution volume) was obtained with single photon emission computed tomography (SPECT) imaging of [I-123]iomazenil binding and measurement of radioligand concentration in plasma. Distribution volume image data were analyzed by means of statistical parametric mapping.Results: Lower distribution volumes were found in the prefrontal cortex (Brodmann's area 9) of PTSD patients than in comparison subjects.Conclusions: These findings of lower values for the benzodiazepine receptor binding measure of distribution volume are consistent with fewer benzodiazepine receptors and/or reduced affinity of receptor binding in the medial prefrontal cortex in patients with PTSD. Alterations in benzodiazepine receptor function in this area may underlie many of the symptoms of PTSD.