Docosahexaenoic acid and arachidonic acid in infant development.
Docosahexaenoic acid and arachidonic acid in infant development.
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DOI：
10.1053/siny.2001.0093
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发表时间：
2001-10-01
期刊：
影响因子：
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通讯作者：
Carlson, S E
中科院分区：
文献类型：
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作者：
Carlson, S E
二十二碳六烯酸和花生四烯酸在中枢神经系统中高度集中。这些脂肪酸在中枢神经系统中的数量在子宫内最后三个月和生命的第一年急剧增加。在过去20年中进行的研究的一个中心问题是，二十二碳六烯酸的必需脂肪酸前体是否足以在中枢神经系统中实现最佳的DHA积累，从而促进婴儿发育。非人类灵长类动物研究的重要作用，在表征n-3必需脂肪酸缺乏症和随后的低脑DHA积累的行为影响，必需脂肪酸缺乏症和二十二碳六烯酸和花生四烯酸的条件性缺乏症之间的差异，以及人类婴儿有条件必需的二十二碳六烯酸，也许，花生四烯酸的证据进行了总结。目前的暗示性证据的几种可能的机制行为的影响也提供了。
Docosahaxaenoic acid and arachidonic acid are highly concentrated in the central nervous system. The amount of these fatty acids in the central nervous system increases dramatically during the last intrauterine trimester and the first year of life. A central question of research conducted during the past 20 years is if the essential fatty acid precursor of docosahexaenoic acid is sufficient to achieve optimal DHA accumulation in the central nervous system and, therefore, infant development. The important role of non-human primate studies in characterising the behavioral effects of n-3 essential fatty acid deficiency and subsequent low brain DHA accumulation, the difference between essential fatty acid deficiencies and conditional deficiencies of docosahexaenoic acid and arachidonic acid, and the evidence that human infants have a conditionally essential need for docosahexaenoic acid and, perhaps, for arachidonic acid are summarised. The current suggestive evidence for several possible mechanisms underlying behavioral effects are also provided.