Binding of an aldose reductase inhibitor to renal glomeruli.
Binding of an aldose reductase inhibitor to renal glomeruli.
复制标题
醛糖还原酶抑制剂与肾小球的结合。
DOI：
10.1016/0006-291x(85)90184-6
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发表时间：
1985
影响因子：
3.1
通讯作者：
Klepser,H
中科院分区：
文献类型：
--
作者：
Cohen,MP;Klepser,H
醛糖还原酶抑制剂Sorbinil影响几种膜相关复合物，包括Na K-ATP酶活性，运输过程和脉冲传播。这些考虑，加上药物的芳香性，表明与细胞膜直接相互作用的可能性。在本研究中，结合[3 H]-Sorbinil分离肾小球被证明。结合具有剂量依赖性和饱和性，并且可以通过增加未标记的Sorbinil的浓度来抑制。这些结果可能有助于解释该化合物对膜相关过程的不同影响。
The aldose reductase inhibitor Sorbinil affects several membrane-associated complexes including Na K-ATPase activity, transport processes, and impulse propagation. These considerations, coupled with the drug's aromatic nature, suggested the possibility of direct interaction with cell membranes. In the present study, binding of [3H]-Sorbinil to isolated glomeruli was demonstrated. Binding is dose-dependent and saturable, and can be inhibited by increasing concentrations of unlabeled Sorbinil. These results may help explain the compound's diverse effects on membrane-associated processes.