The enhanced S cone syndrome: An analysis of receptoral and post-receptoral changes
The enhanced S cone syndrome: An analysis of receptoral and post-receptoral changes
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DOI：
10.1016/0042-6989(96)00073-9
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发表时间：
1996-11-01
期刊：
影响因子：
1.8
通讯作者：
Jacobson, SG
中科院分区：
文献类型：
--
作者：
Greenstein, VC;Zaidi, Q;Jacobson, SG
本研究的目的是检验增强型S锥综合征（ESCS）患者的视网膜比正常视网膜具有更多的S锥，并且这些锥已经取代了一些L和M锥的假设。标准和光谱全视野视网膜电图，测量了3例ESCS患者的L、M和S锥系统灵敏度和S锥敏锐度。这些结果与更多的S视锥和更多的S视锥神经节细胞的存在定性一致。为了进一步验证这一假设，S视锥系统的感受器和后感受器组件的模型与闪光和稳态适应条件下S视锥系统敏感性的心理物理测量结合使用。在该模型的背景下，数据与S视锥和S -（L + M）神经节细胞数量的增加以及每个S -（L + M）神经节细胞的总L + M视锥输入的减少一致。版权所有（C）1996 Elsevier Science Ltd.
The purpose of the study was to test the hypothesis that the retinae of patients with enhanced S cone syndrome (ESCS) have more S cones than the normal retina and these cones have replaced some of the L and M cones, Standard and spectral full-field electroretinograms, measurements of L, M, and S cone system sensitivities and S cone acuity were obtained from three patients with ESCS. The results were qualitatively consistent with the presence of more S cones and more S cone ganglion cells, To test this hypothesis further, a model of the receptoral and post-receptoral components of the S cone system was used in conjunction with psychophysical measurements of S cone system sensitivity under flashed and steady-state adaptation conditions. Within the context of the model, the data were consistent with an increase in the number of S cones and S - (L + M) ganglion cells and with a decrease in the total L + M cone input to each S - (L + M) ganglion cell. Copyright (C) 1996 Elsevier Science Ltd.